Domains within Mus musculus protein INS2_MOUSE (P01326)

Insulin-2

Alternative representations: 1 /

Protein length110 aa
Source databaseUniProt
Identifiers INS2_MOUSE, P01326, ENSMUSP00000101554.1, ENSMUSP00000101554, ENSMUSP00000147425.1, ENSMUSP00000147425, ENSMUSP00000101553.1, ENSMUSP00000101553, ENSMUSP00000000220.2, ENSMUSP00000000220, ENSMUSP00000101552.1, ENSMUSP00000101552, Q5EEX1_MOUSE, Q5EEX1, Q2IDG8_MUSSP, Q2IDG8, D0EY27_MOUSE, D0EY27
Source gene ENSMUSG00000000215
Alternative splicing D3Z595_MOUSE, INS2_MOUSE, D3Z596_MOUSE, D3YWU5_MOUSE, E0CXX7_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

INS2_MOUSE is shown as Ins2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Ins2

Protein INS2_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04211Longevity regulating pathway

KEGG orthologous groups

KONameDescription
K04526INSinsulin

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000147425 in eggNOG.

OGTaxonomic classDescription
714TCAll organisms (root)insulin
5FNT7Eukaryota (superkingdom)insulin
HV42DMetazoa (kingdom)insulin
94KBZChordata (phylum)insulin
5QHQFSarcopterygii (superclass)insulin
8Z24YMammalia (class)insulin
4RBYWEuarchontoglires (superorder)insulin
AIAASRodentia (order)insulin
8DKWDMyomorpha (suborder)insulin
H709FBilateria (clade)insulin
7KBX1Opisthokonta (clade)insulin
9G3K1Vertebrata (clade)insulin
CQE82Muridae (family)insulin
ADX82Murinae (subfamily)insulin
5PJ60Mus (genus)insulin
HEGA8Mus (subgenus)insulin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: