Domains within Bos taurus protein PROF1_BOVIN (P02584)

Profilin-1

Alternative representations: 1 /

Protein length140 aa
Source databaseUniProt
Identifiers PROF1_BOVIN, P02584, ENSBTAP00000006465.4, ENSBTAP00000006465, Q3ZCH4, Q5E942, A0A212D7Q6_CEREH, A0A212D7Q6, L8HZW1_9CETA, L8HZW1
Source gene ENSBTAG00000004915

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

PROF1_BOVIN is shown as PFN1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for PFN1

Protein PROF1_BOVIN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05132Salmonella infection

KEGG orthologous groups

KONameDescription
K05759PFNprofilin

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 29 PTMs annotated in this protein:

PTMCount
Phosphorylation15
Ubiquitination7
Acetylation5
Nitrosylation1
Proteolytic cleavage1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein PFN1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9913.ENSBTAP00000006465 in eggNOG.

OGTaxonomic classDescription
LKOG1755All organisms (root)profilin
KOG1755Eukaryota (superkingdom)profilin
HUUZIMetazoa (kingdom)profilin
94IAWChordata (phylum)profilin
5R6ZTSarcopterygii (superclass)profilin
8ZEKHMammalia (class)profilin
BQKDKLaurasiatheria (superorder)profilin
AX2HNArtiodactyla (order)profilin
B616WPecora (infraorder)profilin
9FQ3TVertebrata (clade)profilin
H4WY4Bilateria (clade)profilin
7KP34Opisthokonta (clade)profilin
7PQVJBovidae (family)profilin
DAWPYBovinae (subfamily)profilin
AZVT0Bos (genus)profilin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: