Domains within Ovis aries protein AT1A1_SHEEP (P04074)

Sodium/potassium-transporting ATPase subunit alpha-1

Alternative representations: 1 /

Protein length1021 aa
Source databaseUniProt
Identifiers AT1A1_SHEEP, P04074, ENSOARP00000021706.1, ENSOARP00000021706
Source gene ENSOARG00000020213
Alternative splicing AT1A1_SHEEP, W5QG59_SHEEP

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

AT1A1_SHEEP is shown as ATP1A1 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ATP1A1

Protein AT1A1_SHEEP is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04971Gastric acid secretion
map04024cAMP signaling pathway
map04961Endocrine and other factor-regulated calcium reabsorption

KEGG orthologous groups

KONameDescription
K01537ATP2CP-type Ca2+ transporter type 2C [EC:7.2.2.10]
K01539ATP1Asodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9940.ENSOARP00000021706 in eggNOG.

OGTaxonomic classDescription
LCOG0474All organisms (root)P-type Ca2+ transporter type 2C [EC:7.2.2.10],phospholipid-translocating ATPase [EC:7.6.2.1],H+-transporting ATPase [EC:7.1.2.1]
KOG0203Eukaryota (superkingdom)sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13],thiamine-triphosphatase [EC:3.6.1.28],non-gastric H+/K+-exchanging ATPase [EC:7.2.2.19]
HW92WMetazoa (kingdom)sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13],non-gastric H+/K+-exchanging ATPase [EC:7.2.2.19],H+/K+-exchanging ATPase subunit alpha [EC:7.2.2.19]
9430YChordata (phylum)sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13],non-gastric H+/K+-exchanging ATPase [EC:7.2.2.19],H+/K+-exchanging ATPase subunit alpha [EC:7.2.2.19]
5QSNWSarcopterygii (superclass)sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13],calsequestrin 1
8Z49XMammalia (class)sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]
BQK3GLaurasiatheria (superorder)sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]
AX713Artiodactyla (order)sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]
B5YKBPecora (infraorder)sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]
H5JH1Bilateria (clade)sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13],non-gastric H+/K+-exchanging ATPase [EC:7.2.2.19],H+/K+-exchanging ATPase subunit alpha [EC:7.2.2.19]
7II52Opisthokonta (clade)sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13],thiamine-triphosphatase [EC:3.6.1.28],non-gastric H+/K+-exchanging ATPase [EC:7.2.2.19]
9FGTRVertebrata (clade)sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13],non-gastric H+/K+-exchanging ATPase [EC:7.2.2.19],H+/K+-exchanging ATPase subunit alpha [EC:7.2.2.19]
7PV5JBovidae (family)sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: