Domains within Oryctolagus cuniculus protein TNFB_RABIT (P10154)

Lymphotoxin-alpha

Alternative representations: 1 /

Protein length197 aa
Source databaseUniProt
Identifiers TNFB_RABIT, P10154, ENSOCUP00000005782.1, ENSOCUP00000005782, A0A0U5JXZ2_RABIT, A0A0U5JXZ2
Source gene ENSOCUG00000006694

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

TNFB_RABIT is shown as LTA in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for LTA

Protein TNFB_RABIT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04061Viral protein interaction with cytokine and cytokine receptor

KEGG orthologous groups

KONameDescription
K05468LTA, TNFBlymphotoxin alpha (TNF superfamily, member 1)

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9986.ENSOCUP00000005782 in eggNOG.

OGTaxonomic classDescription
6Y554All organisms (root)lymphotoxin alpha (TNF superfamily, member 1),tumor necrosis factor superfamily, member 2
5K8PAEukaryota (superkingdom)lymphotoxin alpha (TNF superfamily, member 1),tumor necrosis factor superfamily, member 2
HVKCEMetazoa (kingdom)lymphotoxin alpha (TNF superfamily, member 1),tumor necrosis factor superfamily, member 2
93KJRChordata (phylum)lymphotoxin alpha (TNF superfamily, member 1),tumor necrosis factor superfamily, member 2
5QFZDSarcopterygii (superclass)lymphotoxin alpha (TNF superfamily, member 1)
8ZDGPMammalia (class)lymphotoxin alpha (TNF superfamily, member 1)
4R311Euarchontoglires (superorder)lymphotoxin alpha (TNF superfamily, member 1)
H5RPHBilateria (clade)lymphotoxin alpha (TNF superfamily, member 1),tumor necrosis factor superfamily, member 2
9FA2GVertebrata (clade)lymphotoxin alpha (TNF superfamily, member 1)
7NWUQOpisthokonta (clade)lymphotoxin alpha (TNF superfamily, member 1),tumor necrosis factor superfamily, member 2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: