Domains within Rattus norvegicus protein FOSL1_RAT (P10158)

Fos-related antigen 1

Alternative representations: 1 /

Protein length275 aa
Source databaseUniProt
Identifiers FOSL1_RAT, P10158, ENSRNOP00000027891.1, ENSRNOP00000027891, Q4V8K7
Source gene ENSRNOG00000020552

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

FOSL1_RAT is shown as Fosl1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Fosl1

Protein FOSL1_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04657IL-17 signaling pathway
map04380Osteoclast differentiation
map05031Amphetamine addiction

KEGG orthologous groups

KONameDescription
K09034BATFATF-like basic leucine zipper transcriptional factor
K04502FOSL1fos-like antigen 1

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 25 PTMs annotated in this protein:

PTMCount
Phosphorylation21
Methylation3
Acetylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Fosl1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000027891 in eggNOG.

OGTaxonomic classDescription
LKOG1414All organisms (root)ATF-like basic leucine zipper transcriptional factor,proto-oncogene protein c-fos,cyclic AMP-dependent transcription factor ATF-2
KOG1414Eukaryota (superkingdom)ATF-like basic leucine zipper transcriptional factor,proto-oncogene protein c-fos,cyclic AMP-dependent transcription factor ATF-2
HVSBJMetazoa (kingdom)fos-like antigen 1,ATF-like basic leucine zipper transcriptional factor,fos-like antigen 2
941I2Chordata (phylum)fos-like antigen 1,ATF-like basic leucine zipper transcriptional factor,fos-like antigen 2
5R90SSarcopterygii (superclass)fos-like antigen 1,fos-like antigen 2
8Z59TMammalia (class)fos-like antigen 1
4R75VEuarchontoglires (superorder)fos-like antigen 1
AIF90Rodentia (order)fos-like antigen 1
8D43MMyomorpha (suborder)fos-like antigen 1
7JTAPOpisthokonta (clade)fos-like antigen 1,ATF-like basic leucine zipper transcriptional factor,fos-like antigen 2
9FRNIVertebrata (clade)fos-like antigen 1,ATF-like basic leucine zipper transcriptional factor,fos-like antigen 2
H5KPEBilateria (clade)fos-like antigen 1,ATF-like basic leucine zipper transcriptional factor,fos-like antigen 2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: