Domains within Mus musculus protein IL1B_MOUSE (P10749)

Interleukin-1 beta

Alternative representations: 1 /

Protein length269 aa
Source databaseUniProt
Identifiers IL1B_MOUSE, P10749, ENSMUSP00000028881.7, ENSMUSP00000028881, Q2M4J6, Q3TI17_MOUSE, Q3TI17
Source gene ENSMUSG00000027398

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

IL1B_MOUSE is shown as Il1b in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Il1b

Protein IL1B_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04657IL-17 signaling pathway
map04932Non-alcoholic fatty liver disease

KEGG orthologous groups

KONameDescription
K04519IL1Binterleukin 1 beta

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000028881 in eggNOG.

OGTaxonomic classDescription
76P41All organisms (root)interleukin 1 beta,interleukin 1 alpha
5HUZTEukaryota (superkingdom)interleukin 1 beta,interleukin 1 alpha
HTKW5Metazoa (kingdom)interleukin 1 beta
9453KChordata (phylum)interleukin 1 beta
5R4KUSarcopterygii (superclass)interleukin 1 beta
8Z6E2Mammalia (class)interleukin 1 beta
4R8RDEuarchontoglires (superorder)interleukin 1 beta
AI0HQRodentia (order)interleukin 1 beta
8DCCCMyomorpha (suborder)interleukin 1 beta
H4R78Bilateria (clade)interleukin 1 beta
9FCV5Vertebrata (clade)interleukin 1 beta
7MQSPOpisthokonta (clade)interleukin 1 beta
CQ3CJMuridae (family)interleukin 1 beta
AEDI2Murinae (subfamily)interleukin 1 beta
5PP5KMus (genus)interleukin 1 beta
HE8Z1Mus (subgenus)interleukin 1 beta

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: