Domains within Rattus norvegicus protein FAS_RAT (P12785)
Fatty acid synthase
Alternative representations: 1 /
| Protein length | 2505 aa |
|---|---|
| Source database | UniProt |
| Identifiers | FAS_RAT, P12785, ENSRNOP00000064445.1, ENSRNOP00000064445, O09187, O09190, Q63577, Q64717 |
| Source gene | ENSRNOG00000045636 |
Domain architecture analysis
Display all proteins with similar:
| Domain organisation | Proteins having all the domains as the query in the same order. Additional domains are allowed. |
|---|---|
| Domain composition | Proteins with the same domain composition have at least one copy of each of the domains of the query. |
Predicted functional partners
FAS_RAT is shown as 
Fasn in the network
Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.
The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.
Protein FAS_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:
KEGG pathways
| Pathway | Description | |
|---|---|---|
| map04936 | Alcoholic liver disease | |
| map00061 | Fatty acid biosynthesis | iPath3 |
KEGG orthologous groups
| KO | Name | Description | |
|---|---|---|---|
| K00665 | FASN | fatty acid synthase, animal type [EC:2.3.1.85] | iPath3 |
Orthologous groups
Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000064445 in eggNOG.
| OG | Taxonomic class | Description |
|---|---|---|
| LCOG3321 | All organisms (root) | fatty acid synthase, animal type [EC:2.3.1.85],chalcone synthase [EC:2.3.1.74],phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase E [EC:2.3.1.292] |
| KOG1202 | Eukaryota (superkingdom) | fatty acid synthase, animal type [EC:2.3.1.85],chalcone synthase [EC:2.3.1.74],fungal type III polyketide synthase |
| HVVFZ | Metazoa (kingdom) | fatty acid synthase, animal type [EC:2.3.1.85],tensin,3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] |
| 94B7U | Chordata (phylum) | fatty acid synthase, animal type [EC:2.3.1.85] |
| 5QB7N | Sarcopterygii (superclass) | fatty acid synthase, animal type [EC:2.3.1.85] |
| 8Z5PG | Mammalia (class) | fatty acid synthase, animal type [EC:2.3.1.85] |
| 4RPVH | Euarchontoglires (superorder) | fatty acid synthase, animal type [EC:2.3.1.85] |
| AIF29 | Rodentia (order) | fatty acid synthase, animal type [EC:2.3.1.85] |
| 8DMJC | Myomorpha (suborder) | fatty acid synthase, animal type [EC:2.3.1.85] |
| 7JPI9 | Opisthokonta (clade) | fatty acid synthase, animal type [EC:2.3.1.85],6-methylsalicylic acid synthase [EC:2.3.1.165],hybrid polyketide synthase / nonribosomal peptide synthetase ACE1 |
| 9G6JE | Vertebrata (clade) | fatty acid synthase, animal type [EC:2.3.1.85] |
| H4WD5 | Bilateria (clade) | fatty acid synthase, animal type [EC:2.3.1.85],tensin,3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] |
| CQC2W | Muridae (family) | fatty acid synthase, animal type [EC:2.3.1.85] |
| AE0T8 | Murinae (subfamily) | fatty acid synthase, animal type [EC:2.3.1.85] |
The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.