Domains within Rattus norvegicus protein PACA_RAT (P13589)

Pituitary adenylate cyclase-activating polypeptide

Alternative representations: 1 /

Protein length175 aa
Source databaseUniProt
Identifiers PACA_RAT, P13589, ENSRNOP00000070007.1, ENSRNOP00000070007
Source gene ENSRNOG00000049882
Alternative splicing A0A0H2UI25_RAT, PACA_RAT

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Vertebrata

Predicted functional partners

PACA_RAT is shown as Adcyap1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Adcyap1

Protein PACA_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04080Neuroactive ligand-receptor interaction

KEGG orthologous groups

KONameDescription
K05262ADCYAPpituitary adenylate cyclase-activating polypeptide

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000070007 in eggNOG.

OGTaxonomic classDescription
6X4JGAll organisms (root)vasoactive intestinal peptide,pituitary adenylate cyclase-activating polypeptide
5IZ0PEukaryota (superkingdom)vasoactive intestinal peptide,pituitary adenylate cyclase-activating polypeptide
HUBI8Metazoa (kingdom)vasoactive intestinal peptide,pituitary adenylate cyclase-activating polypeptide
93ITMChordata (phylum)vasoactive intestinal peptide,pituitary adenylate cyclase-activating polypeptide
5R4BESarcopterygii (superclass)pituitary adenylate cyclase-activating polypeptide
8Z637Mammalia (class)pituitary adenylate cyclase-activating polypeptide
4RJZ9Euarchontoglires (superorder)pituitary adenylate cyclase-activating polypeptide
AI1KPRodentia (order)pituitary adenylate cyclase-activating polypeptide
8DKTHMyomorpha (suborder)pituitary adenylate cyclase-activating polypeptide
9GIZZVertebrata (clade)vasoactive intestinal peptide,pituitary adenylate cyclase-activating polypeptide
7GIPBOpisthokonta (clade)vasoactive intestinal peptide,pituitary adenylate cyclase-activating polypeptide
H6BE1Bilateria (clade)vasoactive intestinal peptide,pituitary adenylate cyclase-activating polypeptide
CQ7VMMuridae (family)pituitary adenylate cyclase-activating polypeptide
AE5UVMurinae (subfamily)pituitary adenylate cyclase-activating polypeptide

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: