Domains within Cavia porcellus protein INSRR_CAVPO (P14617)

Insulin receptor-related protein

Alternative representations: 1 /

Protein length1300 aa
Source databaseUniProt
Identifiers INSRR_CAVPO, P14617, ENSCPOP00000002888.2, ENSCPOP00000002888
Source gene ENSCPOG00000003189

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eumetazoa

Predicted functional partners

INSRR_CAVPO is shown as INSRR in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for INSRR

Protein INSRR_CAVPO is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04211Longevity regulating pathway
map04360Axon guidance
map05215Prostate cancer

KEGG orthologous groups

KONameDescription
K05087IGF1R, CD221insulin-like growth factor 1 receptor [EC:2.7.10.1]
K08852ERN1serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]
K05086INSRRinsulin receptor-related receptor [EC:2.7.10.1]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10141.ENSCPOP00000002888 in eggNOG.

OGTaxonomic classDescription
LCOG0478All organisms (root)serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-],RAC serine/threonine-protein kinase [EC:2.7.11.1],pto-interacting protein 1 [EC:2.7.11.1]
KOG4258Eukaryota (superkingdom)insulin-like growth factor 1 receptor [EC:2.7.10.1],insulin receptor [EC:2.7.10.1],insulin receptor-related receptor [EC:2.7.10.1]
HUNB6Metazoa (kingdom)insulin-like growth factor 1 receptor [EC:2.7.10.1],insulin receptor [EC:2.7.10.1],insulin receptor-related receptor [EC:2.7.10.1]
93ZR0Chordata (phylum)insulin-like growth factor 1 receptor [EC:2.7.10.1],insulin receptor [EC:2.7.10.1],insulin receptor-related receptor [EC:2.7.10.1]
5QAP9Sarcopterygii (superclass)insulin-like growth factor 1 receptor [EC:2.7.10.1],insulin receptor [EC:2.7.10.1],insulin receptor-related receptor [EC:2.7.10.1]
8Z697Mammalia (class)insulin receptor-related receptor [EC:2.7.10.1]
4RFJEEuarchontoglires (superorder)insulin receptor-related receptor [EC:2.7.10.1]
AIC8HRodentia (order)insulin receptor-related receptor [EC:2.7.10.1]
EVGIEHystricomorpha (suborder)insulin receptor-related receptor [EC:2.7.10.1]
9GT0MVertebrata (clade)insulin-like growth factor 1 receptor [EC:2.7.10.1],insulin receptor [EC:2.7.10.1],insulin receptor-related receptor [EC:2.7.10.1]
7HTGMOpisthokonta (clade)insulin-like growth factor 1 receptor [EC:2.7.10.1],insulin receptor [EC:2.7.10.1],insulin receptor-related receptor [EC:2.7.10.1]
H5QH1Bilateria (clade)insulin-like growth factor 1 receptor [EC:2.7.10.1],insulin receptor [EC:2.7.10.1],insulin receptor-related receptor [EC:2.7.10.1]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: