Domains within Mus musculus protein ANDR_MOUSE (P19091)

Androgen receptor

Alternative representations: 1 /

Protein length899 aa
Source databaseUniProt
Identifiers ANDR_MOUSE, P19091, ENSMUSP00000052648.7, ENSMUSP00000052648, O55066_APOFL, O55066
Source gene ENSMUSG00000046532

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Metazoa

Predicted functional partners

ANDR_MOUSE is shown as Ar in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Ar

Protein ANDR_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05215Prostate cancer
map05200Pathways in cancer

KEGG orthologous groups

KONameDescription
K08557AR, NR3C4androgen receptor
K08554NR3B3, ESRRGestrogen-related receptor gamma

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 2 PTMs annotated in this protein:

PTMCount
Phosphorylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Ar.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000052648 in eggNOG.

OGTaxonomic classDescription
LKOG3575All organisms (root)estrogen-related receptor gamma,nuclear receptor subfamily 2 group E member 3,retinoid X receptor alpha
KOG3575Eukaryota (superkingdom)estrogen-related receptor gamma,nuclear receptor subfamily 2 group E member 3,retinoid X receptor alpha
HTWGTMetazoa (kingdom)androgen receptor
93V0WChordata (phylum)androgen receptor
5R3U3Sarcopterygii (superclass)androgen receptor
8YYMBMammalia (class)androgen receptor
4RCIVEuarchontoglires (superorder)androgen receptor
AI9NIRodentia (order)androgen receptor
8D6YJMyomorpha (suborder)androgen receptor
7JF4GOpisthokonta (clade)androgen receptor
9FH1TVertebrata (clade)androgen receptor
H5ZYFBilateria (clade)androgen receptor
CQ32VMuridae (family)androgen receptor
AE2E9Murinae (subfamily)androgen receptor
5PUN3Mus (genus)androgen receptor
HE4Z3Mus (subgenus)androgen receptor

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: