Domains within Mus musculus protein MOES_MOUSE (P26041)

Moesin

Alternative representations: 1 /

Protein length577 aa
Source databaseUniProt
Identifiers MOES_MOUSE, P26041, ENSMUSP00000113071.1, ENSMUSP00000113071, B1AX70, Q3UL28, Q8BSN4, Q3UF33_MOUSE, Q3UF33, A0A0P6CBP6_9CRUS, A0A0P6CBP6
Source gene ENSMUSG00000031207

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

MOES_MOUSE is shown as Msn in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Msn

Protein MOES_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05205Proteoglycans in cancer
map04530Tight junction

KEGG orthologous groups

KONameDescription
K23970FRMD4FERM domain-containing protein 4
K08007EZR, VIL2ezrin
K16684NF2merlin
K05763MSNmoesin

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 87 PTMs annotated in this protein:

PTMCount
Ubiquitination37
Phosphorylation34
Acetylation15
Methylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Msn.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000113071 in eggNOG.

OGTaxonomic classDescription
LKOG3529All organisms (root)FERM domain-containing protein 4,merlin,radixin
KOG3529Eukaryota (superkingdom)FERM domain-containing protein 4,merlin,radixin
HW9R1Metazoa (kingdom)merlin,radixin,villin 2 (ezrin)
93Q18Chordata (phylum)moesin,villin 2 (ezrin),radixin
5QP93Sarcopterygii (superclass)moesin
8YXBKMammalia (class)moesin
4RA10Euarchontoglires (superorder)moesin
AI5JERodentia (order)moesin
8D7NHMyomorpha (suborder)moesin
7I6ZDOpisthokonta (clade)merlin,radixin,villin 2 (ezrin)
9GB8BVertebrata (clade)moesin,villin 2 (ezrin),radixin
H4J48Bilateria (clade)merlin,radixin,villin 2 (ezrin)
CQFQYMuridae (family)moesin
AE9D8Murinae (subfamily)moesin
5PRVMMus (genus)moesin
HE0C7Mus (subgenus)moesin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: