Domains within Rattus norvegicus protein IL10_RAT (P29456)

Interleukin-10

Alternative representations: 1 /

Protein length178 aa
Source databaseUniProt
Identifiers IL10_RAT, P29456, ENSRNOP00000006246.2, ENSRNOP00000006246, Q63263
Source gene ENSRNOG00000004647

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Euteleostomi

Predicted functional partners

IL10_RAT is shown as Il10 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Il10

Protein IL10_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05321Inflammatory bowel disease

KEGG orthologous groups

KONameDescription
K05443IL10, CSIFinterleukin 10

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000006246 in eggNOG.

OGTaxonomic classDescription
6X4JKAll organisms (root)interleukin 10
5EHZEEukaryota (superkingdom)interleukin 10
HUM6GMetazoa (kingdom)interleukin 10
941FFChordata (phylum)interleukin 10
5QT4JSarcopterygii (superclass)interleukin 10
8ZC4AMammalia (class)interleukin 10
4R9XAEuarchontoglires (superorder)interleukin 10
AI6E9Rodentia (order)interleukin 10
8DH77Myomorpha (suborder)interleukin 10
9FU1IVertebrata (clade)interleukin 10
7N19AOpisthokonta (clade)interleukin 10
H61YCBilateria (clade)interleukin 10
CQC44Muridae (family)interleukin 10
ADW8RMurinae (subfamily)interleukin 10

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: