Domains within Homo sapiens protein HXA13_HUMAN (P31271)

Homeobox protein Hox-A13

Alternative representations: 1 /

Protein length388 aa
Source databaseUniProt
Identifiers HXA13_HUMAN, P31271, ENSP00000222753.4, ENSP00000222753, A4D188, O43371, G3S4Q8_GORGO, G3S4Q8
Source gene ENSG00000106031

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

HXA13_HUMAN is shown as HOXA13 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for HOXA13

Protein HXA13_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05202Transcriptional misregulation in cancer

KEGG orthologous groups

KONameDescription
K09298HOX_13homeobox protein HoxA/B/C/D13

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 15 PTMs annotated in this protein:

PTMCount
Phosphorylation7
Ubiquitination4
Acetylation4

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein HOXA13.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000497112 in eggNOG.

OGTaxonomic classDescription
LKOG0487All organisms (root)homeobox protein HoxA/B/C/D13,homeobox protein HoxB/C/D9,homeobox protein HoxC/D12
KOG0487Eukaryota (superkingdom)homeobox protein HoxA/B/C/D13,homeobox protein HoxB/C/D9,homeobox protein HoxC/D12
HUHQ5Metazoa (kingdom)homeobox protein HoxA/B/C/D13
93S93Chordata (phylum)homeobox protein HoxA/B/C/D13
5R6K1Sarcopterygii (superclass)homeobox protein HoxA/B/C/D13
8ZD9MMammalia (class)homeobox protein HoxA/B/C/D13
4RDZWEuarchontoglires (superorder)homeobox protein HoxA/B/C/D13
501CCPrimates (order)homeobox protein HoxA/B/C/D13
98RSYHaplorrhini (suborder)homeobox protein HoxA/B/C/D13
BUZ3PSimiiformes (infraorder)homeobox protein HoxA/B/C/D13
9F0WFCatarrhini (parvorder)homeobox protein HoxA/B/C/D13
7J362Opisthokonta (clade)homeobox protein HoxA/B/C/D13
9GEPMVertebrata (clade)homeobox protein HoxA/B/C/D13
H3GHBBilateria (clade)homeobox protein HoxA/B/C/D13
FWXMTHominoidea (superfamily)homeobox protein HoxA/B/C/D13
5MYZYHominidae (family)homeobox protein HoxA/B/C/D13
5Y10CHomininae (subfamily)homeobox protein HoxA/B/C/D13

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: