Domains within Drosophila melanogaster protein SNP25_DROME (P36975)

Synaptosomal-associated protein 25

Alternative representations: 1 /

Protein length212 aa
Source databaseUniProt
Identifiers SNP25_DROME, P36975, FBPP0110435, F3YD56, Q5LJU6, Q7PLV2
Source gene FBgn0011288
Alternative splicing SNP25_DROME, P36975-3

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

SNP25_DROME is shown as Snap25 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Snap25

Protein SNP25_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04721Synaptic vesicle cycle

KEGG orthologous groups

KONameDescription
K18211SNAP25synaptosomal-associated protein 25

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 11 PTMs annotated in this protein:

PTMCount
Phosphorylation4
Palmitoylation3
Ubiquitination3
Acetylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Snap25.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0110435 in eggNOG.

OGTaxonomic classDescription
FUVBWmelanogaster group (species group)synaptosomal-associated protein 25
FDTN6melanogaster subgroup (species subgroup)synaptosomal-associated protein 25
EJ4D0Endopterygota (cohort)synaptosomal-associated protein 25
LKOG3065All organisms (root)synaptosomal-associated protein 25,synaptosomal-associated protein 29,synaptosomal-associated protein 47
KOG3065Eukaryota (superkingdom)synaptosomal-associated protein 25,synaptosomal-associated protein 29,synaptosomal-associated protein 47
HV1HNMetazoa (kingdom)synaptosomal-associated protein 25,nematode chemoreceptor,synaptosomal-associated protein 23
HI7VMArthropoda (phylum)synaptosomal-associated protein 25
85CUXHexapoda (subphylum)synaptosomal-associated protein 25
AH7ECNeoptera (infraclass)synaptosomal-associated protein 25
ANWECDiptera (order)synaptosomal-associated protein 25
H5BITBilateria (clade)synaptosomal-associated protein 25,nematode chemoreceptor,synaptosomal-associated protein 23
7HCWPOpisthokonta (clade)synaptosomal-associated protein 25,nematode chemoreceptor,synaptosomal-associated protein 23
EGWA1Drosophila (genus)synaptosomal-associated protein 25
50BICSophophora (subgenus)synaptosomal-associated protein 25

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: