Domains within Bos taurus protein KGUA_BOVIN (P46195)

Guanylate kinase

Alternative representations: 1 /

Protein length198 aa
Source databaseUniProt
Identifiers KGUA_BOVIN, P46195, ENSBTAP00000036402.1, ENSBTAP00000036402, ENSBTAP00000054864.1, ENSBTAP00000054864, Q3ZCE9, G8JKX7_BOVIN, G8JKX7
Source gene ENSBTAG00000014775
Alternative splicing KGUA_BOVIN, ENSBTAP00000019656.4

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

KGUA_BOVIN is shown as GUK1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for GUK1

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 72004.ENSBMUP00000017683 in eggNOG.

OGTaxonomic classDescription
LCOG0194All organisms (root)guanylate kinase [EC:2.7.4.8],MAGUK p55 subfamily member 2/6,MAGUK p55 subfamily member 3/7
KOG0707Eukaryota (superkingdom)guanylate kinase [EC:2.7.4.8],glycoprotein endo-alpha-1,2-mannosidase [EC:3.2.1.130],membrane-associated guanylate kinase-related
HVX5YMetazoa (kingdom)guanylate kinase [EC:2.7.4.8],thioredoxin domain-containing protein 3,gap junction gamma-2 protein
94VUSChordata (phylum)guanylate kinase [EC:2.7.4.8],gap junction gamma-2 protein
5R1MISarcopterygii (superclass)guanylate kinase [EC:2.7.4.8],gap junction gamma-2 protein
8ZD26Mammalia (class)guanylate kinase [EC:2.7.4.8],gap junction gamma-2 protein
BQSB9Laurasiatheria (superorder)guanylate kinase [EC:2.7.4.8]
AWXFIArtiodactyla (order)guanylate kinase [EC:2.7.4.8]
B60GFPecora (infraorder)guanylate kinase [EC:2.7.4.8]
7NWQ5Opisthokonta (clade)guanylate kinase [EC:2.7.4.8],thioredoxin domain-containing protein 3,gap junction gamma-2 protein
H4P1NBilateria (clade)guanylate kinase [EC:2.7.4.8],gap junction gamma-2 protein
9GU04Vertebrata (clade)guanylate kinase [EC:2.7.4.8],gap junction gamma-2 protein
7PTHXBovidae (family)guanylate kinase [EC:2.7.4.8]
DB444Bovinae (subfamily)guanylate kinase [EC:2.7.4.8]
B00B3Bos (genus)guanylate kinase [EC:2.7.4.8]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: