Domains within Mus musculus protein GLI1_MOUSE (P47806)

Zinc finger protein GLI1

Alternative representations: 1 /

Protein length1111 aa
Source databaseUniProt
Identifiers GLI1_MOUSE, P47806, ENSMUSP00000026474.3, ENSMUSP00000026474, G5E857, Q9QYK1, D4Q8I4_MOUSE, D4Q8I4, A2RRI7_MOUSE, A2RRI7
Source gene ENSMUSG00000025407
Alternative splicing GLI1_MOUSE, ENSMUSP00000151718.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

GLI1_MOUSE is shown as Gli1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Gli1

Protein GLI1_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04340Hedgehog signaling pathway
map05168Herpes simplex virus 1 infection

KEGG orthologous groups

KONameDescription
K09228KRABKRAB domain-containing zinc finger protein
K16798GLI2zinc finger protein GLI2
K16797GLI1zinc finger protein GLI1
K09232GLIS1_3zinc finger protein GLIS1/3

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 28 PTMs annotated in this protein:

PTMCount
Phosphorylation24
Acetylation4

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Gli1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000026474 in eggNOG.

OGTaxonomic classDescription
LKOG1721All organisms (root)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,KRAB and SCAN domains-containing zinc finger protein
KOG1721Eukaryota (superkingdom)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,KRAB and SCAN domains-containing zinc finger protein
HU1A6Metazoa (kingdom)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,IKAROS family zinc finger protein
93QJRChordata (phylum)zinc finger protein GLI2,zinc finger protein GLI3,zinc finger protein GLI1
5QKATSarcopterygii (superclass)zinc finger protein GLI1
8ZI96Mammalia (class)zinc finger protein GLI1
4RAKPEuarchontoglires (superorder)zinc finger protein GLI1
AICZDRodentia (order)zinc finger protein GLI1
8DE4YMyomorpha (suborder)zinc finger protein GLI1
7MTDYOpisthokonta (clade)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,KRAB and SCAN domains-containing zinc finger protein
9FP5VVertebrata (clade)zinc finger protein GLI2,zinc finger protein GLI3,zinc finger protein GLI1
H42RCBilateria (clade)zinc finger protein GLIS1/3,zinc finger protein GLI2,zinc finger protein GLI3
CQ3RIMuridae (family)zinc finger protein GLI1
AE1RCMurinae (subfamily)zinc finger protein GLI1
5PMT2Mus (genus)zinc finger protein GLI1
HE6DKMus (subgenus)zinc finger protein GLI1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: