Domains within Mus musculus protein LUM_MOUSE (P51885)

Lumican

Alternative representations: 1 /

Protein length338 aa
Source databaseUniProt
Identifiers LUM_MOUSE, P51885, ENSMUSP00000040877.4, ENSMUSP00000040877, Q3TP25, Q99JZ3, Q9CXK0
Source gene ENSMUSG00000036446

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

LUM_MOUSE is shown as Lum in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Lum

Protein LUM_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05205Proteoglycans in cancer
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K22038LRRC8volume-regulated anion channel
K08122LUMlumican

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 11 PTMs annotated in this protein:

PTMCount
Sulfation4
N-linked glycosylation4
Phosphorylation2
Pyrrolidone carboxylic acid formation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Lum.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000040877 in eggNOG.

OGTaxonomic classDescription
LCOG1552All organisms (root)volume-regulated anion channel,leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein,protein phosphatase 1 regulatory subunit 7
KOG0619Eukaryota (superkingdom)volume-regulated anion channel,leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein,leucine-rich repeat transmembrane protein FLRT
HSU2PMetazoa (kingdom)lumican
94SZIChordata (phylum)lumican
5R479Sarcopterygii (superclass)lumican
8ZJ4TMammalia (class)lumican
4REIHEuarchontoglires (superorder)lumican
AI8D1Rodentia (order)lumican
8DN80Myomorpha (suborder)lumican
9FWP0Vertebrata (clade)lumican
7M3UPOpisthokonta (clade)lumican
H4UQ3Bilateria (clade)lumican
CQGB1Muridae (family)lumican
AE6KTMurinae (subfamily)lumican
5PSG8Mus (genus)lumican
HE3WJMus (subgenus)lumican

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: