Domains within Mus musculus protein CTNS_MOUSE (P57757)

Cystinosin

Alternative representations: 1 /

Protein length367 aa
Source databaseUniProt
Identifiers CTNS_MOUSE, P57757, ENSMUSP00000006103.2, ENSMUSP00000006103, ENSMUSP00000104116.1, ENSMUSP00000104116, Q542U5_MOUSE, Q542U5
Source gene ENSMUSG00000005949

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

CTNS_MOUSE is shown as Ctns in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Ctns

Protein CTNS_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04142Lysosome

KEGG orthologous groups

KONameDescription
K12386CTNScystinosin

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 3 PTMs annotated in this protein:

PTMCount
N-linked glycosylation3

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Ctns.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000104116 in eggNOG.

OGTaxonomic classDescription
LKOG3145All organisms (root)cystinosin,large subunit ribosomal protein L55
KOG3145Eukaryota (superkingdom)cystinosin,large subunit ribosomal protein L55
HUZ4RMetazoa (kingdom)cystinosin,large subunit ribosomal protein L55
93WW8Chordata (phylum)cystinosin
5R7XESarcopterygii (superclass)cystinosin
8ZJVTMammalia (class)cystinosin
4RK3HEuarchontoglires (superorder)cystinosin
AIA4CRodentia (order)cystinosin
8D7CNMyomorpha (suborder)cystinosin
H4T2DBilateria (clade)cystinosin,large subunit ribosomal protein L55
9FXHUVertebrata (clade)cystinosin
7ICUVOpisthokonta (clade)cystinosin,large subunit ribosomal protein L55
CQ5IIMuridae (family)cystinosin
AE5NFMurinae (subfamily)cystinosin
5PTSYMus (genus)cystinosin
HE07AMus (subgenus)cystinosin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: