Domains within Homo sapiens protein RS4X_HUMAN (P62701)

40S ribosomal protein S4, X isoform

Alternative representations: 1 /

Protein length263 aa
Source databaseUniProt
Identifiers RS4X_HUMAN, P62701, ENSP00000362744.4, ENSP00000362744, P12631, P12750, P27576, P55831, Q14727, Q6IPY4, RS4X_FELCA, P62705, RS4X_CHLAE, Q76N24, RS4X_MACFU, Q76MY1, RS4X_MESAU, P62704, RS4X_MOUSE, P62702, Q9CXN0, RS4X_RAT, P62703, RS4_BOVIN, P79103, A5PJ76, Q3T0A5, B2R491_HUMAN, B2R491, A0A0P6CDI9_9CRUS, A0A0P6CDI9, F6PQP1_CALJA, F6PQP1, H2QYT0_PANTR, H2QYT0, F2X203_AILME, F2X203, I7GKK0_MACFA, I7GKK0, A0A2K6M8D8_RHIBE, A0A2K6M8D8, I2CYD2_MACMU, I2CYD2, F2Z4Q1_CANLF, F2Z4Q1, G3RUZ2_GORGO, G3RUZ2, W5PFW3_SHEEP, W5PFW3, A0A2K5LD40_CERAT, A0A2K5LD40, A0A2K6QHU1_RHIRO, A0A2K6QHU1, A0A096MLU8_PAPAN, A0A096MLU8, A0A2K5QLQ8_CEBCA, A0A2K5QLQ8, A0A2K5HYU2_COLAP, A0A2K5HYU2, A0A2K5Z411_MANLE, A0A2K5Z411, F1RQ91_PIG, F1RQ91, A0A1S2ZXE7_ERIEU, A0A1S2ZXE7, G1S927_NOMLE, G1S927, Q545X8_MOUSE, Q545X8, A0A1S3GTW3_DIPOR, A0A1S3GTW3, A0A250YDX2_CASCN, A0A250YDX2, A0A1U7R570_MESAU, A0A1U7R570, Q96IR1_HUMAN, Q96IR1, W5Q8J9_SHEEP, W5Q8J9, L8I2B8_9CETA, L8I2B8, F7DFM3_HORSE, F7DFM3, G3SQW6_LOXAF, G3SQW6, X1WI37_RAT, X1WI37, A0A287B771_PIG, A0A287B771, Q545F8_MOUSE, Q545F8, K9IR42_DESRO, K9IR42
Source gene ENSG00000198034

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

RS4X_HUMAN is shown as RPS4Y1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for RPS4Y1

Protein RS4X_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05171Coronavirus disease - COVID-19

KEGG orthologous groups

KONameDescription
K02987RP-S4e, RPS4small subunit ribosomal protein S4e

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 229 PTMs annotated in this protein:

PTMCount
Ubiquitination90
Phosphorylation75
Acetylation44
Nitrosylation14
Methylation6

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein RPS4.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000362744 in eggNOG.

OGTaxonomic classDescription
LKOG0378All organisms (root)small subunit ribosomal protein S4e,transcription factor MYB, plant,Cbp/p300-interacting transactivator 1
KOG0378Eukaryota (superkingdom)small subunit ribosomal protein S4e,transcription factor MYB, plant,Cbp/p300-interacting transactivator 1
HTB6MMetazoa (kingdom)small subunit ribosomal protein S4e,Cbp/p300-interacting transactivator 1
94N1XChordata (phylum)small subunit ribosomal protein S4e,Cbp/p300-interacting transactivator 1
5QZYVSarcopterygii (superclass)small subunit ribosomal protein S4e,Cbp/p300-interacting transactivator 1
8YU22Mammalia (class)small subunit ribosomal protein S4e,Cbp/p300-interacting transactivator 1
4RIREEuarchontoglires (superorder)small subunit ribosomal protein S4e,Cbp/p300-interacting transactivator 1
4ZJX6Primates (order)small subunit ribosomal protein S4e
98Q5CHaplorrhini (suborder)small subunit ribosomal protein S4e
BVEE3Simiiformes (infraorder)small subunit ribosomal protein S4e
9EJR4Catarrhini (parvorder)small subunit ribosomal protein S4e
9GNPCVertebrata (clade)small subunit ribosomal protein S4e,Cbp/p300-interacting transactivator 1
H5FI2Bilateria (clade)small subunit ribosomal protein S4e,Cbp/p300-interacting transactivator 1
7GMEXOpisthokonta (clade)small subunit ribosomal protein S4e,Cbp/p300-interacting transactivator 1
FXECPHominoidea (superfamily)small subunit ribosomal protein S4e
5N9BUHominidae (family)small subunit ribosomal protein S4e
5XWY5Homininae (subfamily)small subunit ribosomal protein S4e

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: