Domains within Homo sapiens protein H31_HUMAN (P68431)

Histone H3.1

Alternative representations: 1 /

Protein length136 aa
Source databaseUniProt
Identifiers H31_HUMAN, P68431, ENSP00000484095.1, ENSP00000484095, ENSP00000484638.1, ENSP00000484638, ENSP00000366999.1, ENSP00000366999, ENSP00000489282.1, ENSP00000489282, ENSP00000482271.1, ENSP00000482271, ENSP00000483283.1, ENSP00000483283, ENSP00000480826.1, ENSP00000480826, ENSP00000484841.1, ENSP00000484841, ENSP00000484658.1, ENSP00000484658, ENSP00000358160.2, ENSP00000358160, ENSP00000352252.2, ENSP00000352252, A0PJT7, A5PLR1, P02296, P16106, Q6ISV8, Q6NWP8, Q6NWP9, Q6NXU4, Q71DJ3, Q93081, H31_BOVIN, P68432, A1L0V4_MOUSE, A1L0V4, H31_MOUSE, P68433, Q05A97, Q3B7Z8, Q3B7Z9, Q5T009, H31_MUSPA, Q6LBF0, H31_RAT, Q6LED0, L5M3X4_MYODS, L5M3X4, S9WX72_CAMFR, S9WX72, A0A096MPD3_PAPAN, A0A096MPD3, A0A0D9SCL0_CHLSB, A0A0D9SCL0, J9PB22_CANLF, J9PB22, H2QQ69_PANTR, H2QQ69, A0A1U7TPT8_TARSY, A0A1U7TPT8, F7FYT1_CALJA, F7FYT1, F7BRX2_MACMU, F7BRX2, A0A2K5C6D3_AOTNA, A0A2K5C6D3, A0A2K6AT82_MACNE, A0A2K6AT82, L8Y720_TUPCH, L8Y720, G3SCC9_GORGO, G3SCC9, D2HWJ2_AILME, D2HWJ2, A0A2K6S6Q7_SAIBB, A0A2K6S6Q7, A0A2K6NJG1_RHIRO, A0A2K6NJG1, A0A2K6EG15_PROCO, A0A2K6EG15, A0A2K5XBV3_MANLE, A0A2K5XBV3, A0A2K5KPN4_CERAT, A0A2K5KPN4, F1RVA0_PIG, F1RVA0, F2Z576, L5JT92_PTEAL, L5JT92, A0A1S3AGF4_ERIEU, A0A1S3AGF4, H0WXG7_OTOGA, H0WXG7, G1TWR1_RABIT, G1TWR1, G7P2M7_MACFA, G7P2M7, F6Y7V5_HORSE, F6Y7V5, M3XAW8_FELCA, M3XAW8, G1SAW5_NOMLE, G1SAW5, G3TR59_LOXAF, G3TR59, G1QAE2_MYOLU, G1QAE2, H2PI50_PONAB, H2PI50, A0A2K5HIC7_COLAP, A0A2K5HIC7, A0A2K5PIY5_CEBCA, A0A2K5PIY5, A0A2K6K4T2_RHIBE, A0A2K6K4T2, A0A2F0AZK2_ESCRO, A0A2F0AZK2, S7MY93_MYOBR, S7MY93, W6FIK3_PANTA, W6FIK3, L8IRE7_9CETA, L8IRE7, A0A286X9R2_CAVPO, A0A286X9R2, I3MVX5_ICTTR, I3MVX5, G5BV26_HETGA, G5BV26, G3HPV9_CRIGR, G3HPV9, A0A091DP01_FUKDA, A0A091DP01, A0A1U7QFI3_MESAU, A0A1U7QFI3
Source gene ENSG00000277775

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

H31_HUMAN is shown as LOC101322612 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for LOC101322612

Protein H31_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05131Shigellosis
map05034Alcoholism

KEGG orthologous groups

KONameDescription
K11253H3histone H3

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 795 PTMs annotated in this protein:

PTMCount
Methylation258
Phosphorylation189
Acetylation177
Ubiquitination130
Citrullination29
SUMOylation10
Allysine2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSG00000182572.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000484841 in eggNOG.

OGTaxonomic classDescription
7553BAll organisms (root)histone H3,histone H3-like centromeric protein A,myeloid differentiation primary response protein MyD88
KOG1745Eukaryota (superkingdom)histone H3,histone H3-like centromeric protein A,myeloid differentiation primary response protein MyD88
HTU4IMetazoa (kingdom)histone H3,histone H3-like centromeric protein A,histone H2B
94RCFChordata (phylum)histone H3,histone H3-like centromeric protein A,histone H4
5QE61Sarcopterygii (superclass)histone H3,histone H3-like centromeric protein A,histone H4
8ZFGAMammalia (class)histone H3,histone H2A,histone H4
4RQD6Euarchontoglires (superorder)histone H3
500WFPrimates (order)histone H3
98GUFHaplorrhini (suborder)histone H3
BVH87Simiiformes (infraorder)histone H3
9EF6YCatarrhini (parvorder)histone H3
7NUBFOpisthokonta (clade)histone H3,histone H3-like centromeric protein A,histone H2B
H5AK3Bilateria (clade)histone H3,histone H3-like centromeric protein A,histone H2B
9FS0NVertebrata (clade)histone H3,histone H3-like centromeric protein A,histone H4
FX1PTHominoidea (superfamily)histone H3

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: