Domains within Mus musculus protein STIM1_MOUSE (P70302)

Stromal interaction molecule 1

Alternative representations: 1 /

Protein length685 aa
Source databaseUniProt
Identifiers STIM1_MOUSE, P70302, ENSMUSP00000033289.4, ENSMUSP00000033289, Q8K1E1
Source gene ENSMUSG00000030987
Alternative splicing STIM1_MOUSE, A0A1B0GRA5_MOUSE, A0A1B0GR78_MOUSE, A0A1B0GQZ3_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

STIM1_MOUSE is shown as Stim1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Stim1

Protein STIM1_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04020Calcium signaling pathway
map04611Platelet activation

KEGG orthologous groups

KONameDescription
K18196STIM2stromal interaction molecule 2
K16059STIM1stromal interaction molecule 1

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 41 PTMs annotated in this protein:

PTMCount
Phosphorylation31
Ubiquitination5
Acetylation3
N-linked glycosylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Stim1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000033289 in eggNOG.

OGTaxonomic classDescription
LKOG4403All organisms (root)stromal interaction molecule 2,stromal interaction molecule 1
KOG4403Eukaryota (superkingdom)stromal interaction molecule 2,stromal interaction molecule 1
HT089Metazoa (kingdom)stromal interaction molecule 2,stromal interaction molecule 1
93UGJChordata (phylum)stromal interaction molecule 2,stromal interaction molecule 1
5QHX8Sarcopterygii (superclass)stromal interaction molecule 1
8YZ54Mammalia (class)stromal interaction molecule 1
4RIK7Euarchontoglires (superorder)stromal interaction molecule 1
AIBRIRodentia (order)stromal interaction molecule 1
8DJJ2Myomorpha (suborder)stromal interaction molecule 1
H46J8Bilateria (clade)stromal interaction molecule 2,stromal interaction molecule 1
7MF65Opisthokonta (clade)stromal interaction molecule 2,stromal interaction molecule 1
9G4N9Vertebrata (clade)stromal interaction molecule 2,stromal interaction molecule 1
CQ96PMuridae (family)stromal interaction molecule 1
AED7PMurinae (subfamily)stromal interaction molecule 1
5PNC1Mus (genus)stromal interaction molecule 1
HEE4GMus (subgenus)stromal interaction molecule 1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: