Domains within Mus musculus protein DLX5_MOUSE (P70396)

Homeobox protein DLX-5

Alternative representations: 1 /

Protein length289 aa
Source databaseUniProt
Identifiers DLX5_MOUSE, P70396, ENSMUSP00000052559.8, ENSMUSP00000052559, O54876, O54877, O54878, Q9JJ45, Q3TYA7_MOUSE, Q3TYA7
Source gene ENSMUSG00000029755
Alternative splicing P70396-3, DLX5_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

DLX5_MOUSE is shown as Dlx5 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Dlx5

Protein DLX5_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04550Signaling pathways regulating pluripotency of stem cells

KEGG orthologous groups

KONameDescription
K18489DLX5homeobox protein DLX5
K09314DLX1_4_6homeobox protein DLX1/4/6

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 11 PTMs annotated in this protein:

PTMCount
Phosphorylation8
SUMOylation1
Ubiquitination1
Acetylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Dlx5.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000052559 in eggNOG.

OGTaxonomic classDescription
LKOG0850All organisms (root)homeobox protein DLX1/4/6,homeobox protein DLX2,homeobox protein DLX3
KOG0850Eukaryota (superkingdom)homeobox protein DLX1/4/6,homeobox protein DLX2,homeobox protein DLX3
HVT3RMetazoa (kingdom)homeobox protein DLX5
94HG3Chordata (phylum)homeobox protein DLX5
5R7E3Sarcopterygii (superclass)homeobox protein DLX5
8YWDDMammalia (class)homeobox protein DLX5
4RBD0Euarchontoglires (superorder)homeobox protein DLX5
AIAV2Rodentia (order)homeobox protein DLX5
8DM8KMyomorpha (suborder)homeobox protein DLX5
7H1ZAOpisthokonta (clade)homeobox protein DLX5
H5824Bilateria (clade)homeobox protein DLX5
9FJWMVertebrata (clade)homeobox protein DLX5
CQ171Muridae (family)homeobox protein DLX5
AE7P6Murinae (subfamily)homeobox protein DLX5
5PWF6Mus (genus)homeobox protein DLX5
HE7XYMus (subgenus)homeobox protein DLX5

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: