Domains within Homo sapiens protein DEF5_HUMAN (Q01523)

Defensin-5

Alternative representations: 1 /

Protein length94 aa
Source databaseUniProt
Identifiers DEF5_HUMAN, Q01523, ENSP00000329890.2, ENSP00000329890, ENSP00000494799.1, ENSP00000494799, A0JDY6, Q3KNV2
Source gene ENSG00000164816

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

DEF5_HUMAN is shown as DEFA5 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for DEFA5

Protein DEF5_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04621NOD-like receptor signaling pathway

KEGG orthologous groups

KONameDescription
K05230DEFAdefensin, alpha

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000329890 in eggNOG.

OGTaxonomic classDescription
6WZ8NAll organisms (root)defensin, alpha
5H56GEukaryota (superkingdom)defensin, alpha
HVMUVMetazoa (kingdom)defensin, alpha
94TJGChordata (phylum)defensin, alpha
5QWUCSarcopterygii (superclass)defensin, alpha
8ZIYAMammalia (class)defensin, alpha
4R7MGEuarchontoglires (superorder)defensin, alpha
504GVPrimates (order)defensin, alpha
98ASCHaplorrhini (suborder)defensin, alpha
BVFM5Simiiformes (infraorder)defensin, alpha
9EQ9CCatarrhini (parvorder)defensin, alpha
H6FPSBilateria (clade)defensin, alpha
9GIFVVertebrata (clade)defensin, alpha
7IQ7YOpisthokonta (clade)defensin, alpha
FXBTCHominoidea (superfamily)defensin, alpha
5N4YAHominidae (family)defensin, alpha
5XWXIHomininae (subfamily)defensin, alpha

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: