Domains within Homo sapiens protein DEF6_HUMAN (Q01524)

Defensin-6

Alternative representations: 1 /

Protein length100 aa
Source databaseUniProt
Identifiers DEF6_HUMAN, Q01524, ENSP00000297436.2, ENSP00000297436, ENSP00000494361.1, ENSP00000494361, Q6EZF9
Source gene ENSG00000164822

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

DEF6_HUMAN is shown as DEFA6 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for DEFA6

Protein DEF6_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04621NOD-like receptor signaling pathway

KEGG orthologous groups

KONameDescription
K05230DEFAdefensin, alpha

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000297436 in eggNOG.

OGTaxonomic classDescription
6YGARAll organisms (root)defensin, alpha
5IPFBEukaryota (superkingdom)defensin, alpha
HVHP5Metazoa (kingdom)defensin, alpha
93FTZChordata (phylum)defensin, alpha
5QR70Sarcopterygii (superclass)defensin, alpha
8ZIYBMammalia (class)defensin, alpha
4REPMEuarchontoglires (superorder)defensin, alpha
4ZKG4Primates (order)defensin, alpha
98G3IHaplorrhini (suborder)defensin, alpha
BVAIASimiiformes (infraorder)defensin, alpha
9EZKKCatarrhini (parvorder)defensin, alpha
H69E1Bilateria (clade)defensin, alpha
9FC97Vertebrata (clade)defensin, alpha
7M7CROpisthokonta (clade)defensin, alpha
FX2I8Hominoidea (superfamily)defensin, alpha
5N08VHominidae (family)defensin, alpha
5Y0KIHomininae (subfamily)defensin, alpha

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: