Domains within Gallus gallus protein YRK_CHICK (Q02977)
Proto-oncogene tyrosine-protein kinase Yrk
Alternative representations: 1 /
| Protein length | 536 aa |
|---|---|
| Source database | UniProt |
| Identifiers | YRK_CHICK, Q02977, ENSGALP00000043829.1, ENSGALP00000043829 |
| Source gene | ENSGALG00000032199 |
| Alternative splicing | A0A1D5P353_CHICK, YRK_CHICK |
Domain architecture analysis
Display all proteins with similar:
| Domain organisation | Proteins having all the domains as the query in the same order. Additional domains are allowed. |
|---|---|
| Domain composition | Proteins with the same domain composition have at least one copy of each of the domains of the query. |
This domain architecture was probably invented with the emergence of Metazoa
Predicted functional partners
YRK_CHICK is shown as 
FGR in the network
Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.
The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.
Protein YRK_CHICK is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:
KEGG pathways
| Pathway | Description | |
|---|---|---|
| map05416 | Viral myocarditis | |
| map05120 | Epithelial cell signaling in Helicobacter pylori infection | |
| map04360 | Axon guidance | |
| map04062 | Chemokine signaling pathway |
KEGG orthologous groups
| KO | Name | Description | |
|---|---|---|---|
| K08895 | SRMS | tyrosine-protein kinase Srms [EC:2.7.10.2] | |
| K05728 | CSK | c-src tyrosine kinase [EC:2.7.10.2] | |
| K05704 | SRC | tyrosine-protein kinase Src [EC:2.7.10.2] | |
| K08852 | ERN1 | serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-] | |
| K05703 | FYN | tyrosine-protein kinase Fyn [EC:2.7.10.2] | |
| K08892 | FRK, PTK5 | fyn-related kinase [EC:2.7.10.2] |
Orthologous groups
Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9031.ENSGALP00000043829 in eggNOG.
| OG | Taxonomic class | Description |
|---|---|---|
| LCOG0478 | All organisms (root) | serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-],RAC serine/threonine-protein kinase [EC:2.7.11.1],pto-interacting protein 1 [EC:2.7.11.1] |
| KOG0197 | Eukaryota (superkingdom) | fyn-related kinase [EC:2.7.10.2],c-src tyrosine kinase [EC:2.7.10.2],Janus kinase 2 [EC:2.7.10.2] |
| HSSCZ | Metazoa (kingdom) | fyn-related kinase [EC:2.7.10.2],tyrosine-protein kinase Src [EC:2.7.10.2],tyrosine-protein kinase Yes [EC:2.7.10.2] |
| 94SPM | Chordata (phylum) | tyrosine-protein kinase Fyn [EC:2.7.10.2],tyrosine-protein kinase Srms [EC:2.7.10.2],protein tyrosine kinase 6 [EC:2.7.10.2] |
| 5QQN7 | Sarcopterygii (superclass) | tyrosine-protein kinase Srms [EC:2.7.10.2],tyrosine-protein kinase Fyn [EC:2.7.10.2],tyrosine-protein kinase Fgr [EC:2.7.10.2] |
| 6BJ75 | Aves (class) | proto-oncogene tyrosine-protein kinase YRK [EC:2.7.10.2],tyrosine-protein kinase Fyn [EC:2.7.10.2] |
| 8RDR3 | Neognathae (infraclass) | proto-oncogene tyrosine-protein kinase YRK [EC:2.7.10.2],tyrosine-protein kinase Fyn [EC:2.7.10.2] |
| BIRZ3 | Galloanserae (superorder) | proto-oncogene tyrosine-protein kinase YRK [EC:2.7.10.2] |
| AJ2HV | Galliformes (order) | proto-oncogene tyrosine-protein kinase YRK [EC:2.7.10.2] |
| 7IBRR | Opisthokonta (clade) | c-src tyrosine kinase [EC:2.7.10.2],fyn-related kinase [EC:2.7.10.2],tyrosine-protein kinase Src [EC:2.7.10.2] |
| H5CVP | Bilateria (clade) | tyrosine-protein kinase Src [EC:2.7.10.2],fyn-related kinase [EC:2.7.10.2],tyrosine-protein kinase Yes [EC:2.7.10.2] |
| 9FM48 | Vertebrata (clade) | tyrosine-protein kinase Fyn [EC:2.7.10.2],tyrosine-protein kinase Srms [EC:2.7.10.2],protein tyrosine kinase 6 [EC:2.7.10.2] |
| 8722Z | Phasianidae (family) | proto-oncogene tyrosine-protein kinase YRK [EC:2.7.10.2] |
| 9200Q | Phasianinae (subfamily) | proto-oncogene tyrosine-protein kinase YRK [EC:2.7.10.2] |
The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.