Domains within Homo sapiens protein CDC16_HUMAN (Q13042)

Cell division cycle protein 16 homolog

Alternative representations: 1 /

Protein length620 aa
Source databaseUniProt
Identifiers CDC16_HUMAN, Q13042, ENSP00000348554.3, ENSP00000348554, ENSP00000353549.3, ENSP00000353549, A2A365, Q5T8C8, Q7Z651, Q96AE6, Q9Y564, A0A024RDZ2_HUMAN, A0A024RDZ2, A0A2I3RDI6_PANTR, A0A2I3RDI6, A0A2J8X7P7_PONAB, A0A2J8X7P7, A0A2J8KSW0_PANTR, A0A2J8KSW0, Q13042-4
Source gene ENSG00000130177
Alternative splicing CDC16_HUMAN, ENSP00000364459.1, ENSP00000252457.5, Q5T8C6_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

CDC16_HUMAN is shown as CDC16 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for CDC16

Protein CDC16_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04111Cell cycle - yeast

KEGG orthologous groups

KONameDescription
K03353APC6, CDC16anaphase-promoting complex subunit 6

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 38 PTMs annotated in this protein:

PTMCount
Phosphorylation22
Ubiquitination14
Nitrosylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSPTRG00000006072.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000348554 in eggNOG.

OGTaxonomic classDescription
LKOG1173All organisms (root)anaphase-promoting complex subunit 6,small subunit ribosomal protein S15Ae
KOG1173Eukaryota (superkingdom)anaphase-promoting complex subunit 6,small subunit ribosomal protein S15Ae
HUE2WMetazoa (kingdom)anaphase-promoting complex subunit 6
93I88Chordata (phylum)anaphase-promoting complex subunit 6
5QVWPSarcopterygii (superclass)anaphase-promoting complex subunit 6
8Z664Mammalia (class)anaphase-promoting complex subunit 6
4R9CQEuarchontoglires (superorder)anaphase-promoting complex subunit 6
4ZSBMPrimates (order)anaphase-promoting complex subunit 6
988NCHaplorrhini (suborder)anaphase-promoting complex subunit 6
BV8V3Simiiformes (infraorder)anaphase-promoting complex subunit 6
9EJFPCatarrhini (parvorder)anaphase-promoting complex subunit 6
H6ME3Bilateria (clade)anaphase-promoting complex subunit 6
7MDW7Opisthokonta (clade)anaphase-promoting complex subunit 6
9G5SAVertebrata (clade)anaphase-promoting complex subunit 6
FX320Hominoidea (superfamily)anaphase-promoting complex subunit 6
5N5TSHominidae (family)anaphase-promoting complex subunit 6
5XX9XHomininae (subfamily)anaphase-promoting complex subunit 6

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: