Domains within Homo sapiens protein RB33A_HUMAN (Q14088)

Ras-related protein Rab-33A

Alternative representations: 1 /

Protein length237 aa
Source databaseUniProt
Identifiers RB33A_HUMAN, Q14088, ENSP00000257017.4, ENSP00000257017, Q5JUZ6, Q92465, E2R535_CANLF, E2R535
Source gene ENSG00000134594

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

RB33A_HUMAN is shown as RAB33A in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for RAB33A

Protein RB33A_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04140Autophagy - animal

KEGG orthologous groups

KONameDescription
K07919RAB33ARas-related protein Rab-33A
K07874RAB1ARas-related protein Rab-1A
K07920RAB33BRas-related protein Rab-33B

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 6 PTMs annotated in this protein:

PTMCount
Phosphorylation6

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSCAFG00000018755.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000257017 in eggNOG.

OGTaxonomic classDescription
LKOG0084All organisms (root)Ras-related protein Rab-1A,Ras-related protein Rab-33B,Ras-related protein Rab-19
KOG0084Eukaryota (superkingdom)Ras-related protein Rab-1A,Ras-related protein Rab-33B,Ras-related protein Rab-19
HTR3MMetazoa (kingdom)Ras-related protein Rab-33B,Ras-related protein Rab-33A
93KREChordata (phylum)Ras-related protein Rab-33A,Ras-related protein Rab-33B
5QU5USarcopterygii (superclass)Ras-related protein Rab-33A
8Z6GPMammalia (class)Ras-related protein Rab-33A
4RMD8Euarchontoglires (superorder)Ras-related protein Rab-33A
501UKPrimates (order)Ras-related protein Rab-33A
9858ZHaplorrhini (suborder)Ras-related protein Rab-33A
BVAQESimiiformes (infraorder)Ras-related protein Rab-33A
9EMFGCatarrhini (parvorder)Ras-related protein Rab-33A
H5P89Bilateria (clade)Ras-related protein Rab-33B,Ras-related protein Rab-33A
7K156Opisthokonta (clade)Ras-related protein Rab-33B,Ras-related protein Rab-33A
9G1YSVertebrata (clade)Ras-related protein Rab-33A
FWXZZHominoidea (superfamily)Ras-related protein Rab-33A
5N8NPHominidae (family)Ras-related protein Rab-33A
5XSGEHomininae (subfamily)Ras-related protein Rab-33A

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: