Domains within Homo sapiens protein TAF5_HUMAN (Q15542)

Transcription initiation factor TFIID subunit 5

Alternative representations: 1 /

Protein length800 aa
Source databaseUniProt
Identifiers TAF5_HUMAN, Q15542, ENSP00000358854.3, ENSP00000358854, A8K5B4, B2RMR0, B7ZKJ6, Q53EM4, Q5SYD5, Q86UZ7, Q9Y4K5, A0A0D9QZ80_CHLSB, A0A0D9QZ80, G3QRR7_GORGO, G3QRR7, F7C0P5_MACMU, F7C0P5
Source gene ENSG00000148835

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

TAF5_HUMAN is shown as TAF5 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for TAF5

Protein TAF5_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04111Cell cycle - yeast
map03022Basal transcription factors

KEGG orthologous groups

KONameDescription
K03363CDC20cell division cycle 20, cofactor of APC complex
K03130TAF5transcription initiation factor TFIID subunit 5

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 7 PTMs annotated in this protein:

PTMCount
Phosphorylation6
SUMOylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein TAF5.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000358854 in eggNOG.

OGTaxonomic classDescription
LCOG2319All organisms (root)cell division cycle 20, cofactor of APC complex,cell division cycle 20-like protein 1, cofactor of APC complex,transcription initiation factor TFIID subunit 5
KOG0263Eukaryota (superkingdom)transcription initiation factor TFIID subunit 5,sperm-associated antigen 16 protein,WD repeat-containing protein 54
HTD67Metazoa (kingdom)transcription initiation factor TFIID subunit 5
93JUGChordata (phylum)transcription initiation factor TFIID subunit 5
5R22WSarcopterygii (superclass)transcription initiation factor TFIID subunit 5
8ZJFTMammalia (class)transcription initiation factor TFIID subunit 5
4R29UEuarchontoglires (superorder)transcription initiation factor TFIID subunit 5
500N5Primates (order)transcription initiation factor TFIID subunit 5
98JVCHaplorrhini (suborder)transcription initiation factor TFIID subunit 5
BUZ3USimiiformes (infraorder)transcription initiation factor TFIID subunit 5
9EH70Catarrhini (parvorder)transcription initiation factor TFIID subunit 5
9GIPWVertebrata (clade)transcription initiation factor TFIID subunit 5
H4WQPBilateria (clade)transcription initiation factor TFIID subunit 5
7J2QWOpisthokonta (clade)transcription initiation factor TFIID subunit 5
FX2ARHominoidea (superfamily)transcription initiation factor TFIID subunit 5
5N50IHominidae (family)transcription initiation factor TFIID subunit 5
5Y1D3Homininae (subfamily)transcription initiation factor TFIID subunit 5

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: