Domains within Caenorhabditis elegans protein Q21361_CAEEL (Q21361)

ATF (cAMP-dependent transcription factor) family

Alternative representations: 1 /

Protein length401 aa
Source databaseUniProt
Identifiers Q21361_CAEEL, Q21361, K08F8.2, K08F8
Source gene WBGene00000220

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Caenorhabditis

Predicted functional partners

Q21361_CAEEL is shown as atf-2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for atf-2

Protein Q21361_CAEEL is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04711Circadian rhythm - fly
map05202Transcriptional misregulation in cancer

KEGG orthologous groups

KONameDescription
K09059NFIL3, E4BP4nuclear factor, interleukin 3 regulated
K09057HLFhepatic leukemia factor

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 3 PTMs annotated in this protein:

PTMCount
Methylation2
Phosphorylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein atf-2.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 6239.K08F8.2.1 in eggNOG.

OGTaxonomic classDescription
LKOG3119All organisms (root)hepatic leukemia factor,CCAAT/enhancer binding protein (C/EBP), gamma,thyrotrophic embryonic factor
KOG3119Eukaryota (superkingdom)hepatic leukemia factor,CCAAT/enhancer binding protein (C/EBP), gamma,thyrotrophic embryonic factor
HTKEMMetazoa (kingdom)vrille,nuclear factor, interleukin 3 regulated,polycomb group RING finger protein 2
8AIUENematoda (phylum)nuclear factor, interleukin 3 regulated
HDJAKChromadorea (class)nuclear factor, interleukin 3 regulated
6DYQSRhabditida (order)bZIP_2
8PJ3KRhabditina (suborder)bZIP_2
H6J75Bilateria (clade)vrille,nuclear factor, interleukin 3 regulated,polycomb group RING finger protein 2
7NZR1Opisthokonta (clade)vrille,nuclear factor, interleukin 3 regulated,polycomb group RING finger protein 2
AYIMWRhabditidae (family)bZIP_2
BTBS8Caenorhabditis (genus)bZIP_2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: