Domains within Drosophila melanogaster protein NETA_DROME (Q24567)

Netrin-A

Alternative representations: 1 /

Protein length726 aa
Source databaseUniProt
Identifiers NETA_DROME, Q24567, FBPP0311922, FBPP0073759, Q7JXY0, Q94528, Q9VY25, X2JEZ9_DROME, X2JEZ9
Source gene FBgn0015773
Alternative splicing NETA_DROME, M9NF48_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

NETA_DROME is shown as NetA in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for NetA

Protein NETA_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04361Axon regeneration
map04151PI3K-Akt signaling pathway

KEGG orthologous groups

KONameDescription
K05636LAMB1laminin, beta 1
K06843NTN1netrin 1

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 4 PTMs annotated in this protein:

PTMCount
Phosphorylation2
N-linked glycosylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein NetA.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0311922 in eggNOG.

OGTaxonomic classDescription
EJ0PXEndopterygota (cohort)netrin 1
LKOG0994All organisms (root)laminin, beta 1,cilia- and flagella-associated protein 58,netrin 4
FDZWBmelanogaster subgroup (species subgroup)netrin 1
FUWFFmelanogaster group (species group)netrin 1
KOG0994Eukaryota (superkingdom)laminin, beta 1,cilia- and flagella-associated protein 58,netrin 4
HU6GNMetazoa (kingdom)netrin 1
HHSE8Arthropoda (phylum)netrin 1
85HAQHexapoda (subphylum)netrin 1
AHNRCNeoptera (infraclass)netrin 1
ANEVNDiptera (order)netrin 1
7NJZGOpisthokonta (clade)netrin 1
H6DJCBilateria (clade)netrin 1
EH5M2Drosophila (genus)netrin 1
50JA1Sophophora (subgenus)netrin 1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: