Domains within Homo sapiens protein CKS2_HUMAN (P33552)

Cyclin-dependent kinases regulatory subunit 2

Alternative representations: 1 /

Protein length79 aa
Source databaseUniProt
Identifiers CKS2_HUMAN, P33552, ENSP00000364976.3, ENSP00000364976, Q6FGI9, Q6LET5, CKS2_BOVIN, Q2KJI1, A0A2K6UBJ9_SAIBB, A0A2K6UBJ9, G7PSN6_MACFA, G7PSN6, H2QXF4_PANTR, H2QXF4, F7E906_MACMU, F7E906, F7HV56_CALJA, F7HV56, H2PXR6_PONAB, H2PXR6, G3S076_GORGO, G3S076, H0XV44_OTOGA, H0XV44, A0A2K5VH54_MACFA, A0A2K5VH54, L5JV63_PTEAL, L5JV63, A0A2K6JW76_RHIBE, A0A2K6JW76, A0A2K6BX13_MACNE, A0A2K6BX13, A0A2K5MMK5_CERAT, A0A2K5MMK5, A0A2K6QUX2_RHIRO, A0A2K6QUX2, A0A2K5DIX8_AOTNA, A0A2K5DIX8, A0A2I3MB67_PAPAN, A0A2I3MB67, S7NL00_MYOBR, S7NL00, A0A2K6EUV8_PROCO, A0A2K6EUV8, A0A212CMC3_CEREH, A0A212CMC3, A0A2K5J6A5_COLAP, A0A2K5J6A5, A0A2K5PM31_CEBCA, A0A2K5PM31, A0A2K5Z552_MANLE, A0A2K5Z552, F1RN17_PIG, F1RN17, L8HW97_9CETA, L8HW97, A0A1S3ASH2_ERIEU, A0A1S3ASH2, G3TAG6_LOXAF, G3TAG6
Source gene ENSG00000123975

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

CKS2_HUMAN is shown as CKS2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for CKS2

Protein CKS2_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04111Cell cycle - yeast

KEGG orthologous groups

KONameDescription
K02219CKS1cyclin-dependent kinase regulatory subunit CKS1

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 48 PTMs annotated in this protein:

PTMCount
Phosphorylation32
Ubiquitination12
Acetylation4

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSPTRG00000021093.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000364976 in eggNOG.

OGTaxonomic classDescription
LKOG3484All organisms (root)cyclin-dependent kinase regulatory subunit CKS1,glycine N-acyltransferase-like protein 3 [EC:2.3.1.-],glutamine N-acyltransferase [EC:2.3.1.68]
KOG3484Eukaryota (superkingdom)cyclin-dependent kinase regulatory subunit CKS1,glycine N-acyltransferase-like protein 3 [EC:2.3.1.-],glutamine N-acyltransferase [EC:2.3.1.68]
HVBD1Metazoa (kingdom)cyclin-dependent kinase regulatory subunit CKS1,glycine N-acyltransferase / glycine N-benzoyltransferase [EC:2.3.1.13 2.3.1.71]
9427DChordata (phylum)cyclin-dependent kinase regulatory subunit CKS1
5R1Y0Sarcopterygii (superclass)cyclin-dependent kinase regulatory subunit CKS1
8ZKV0Mammalia (class)cyclin-dependent kinase regulatory subunit CKS1
4R5Z8Euarchontoglires (superorder)cyclin-dependent kinase regulatory subunit CKS1
4ZKCGPrimates (order)cyclin-dependent kinase regulatory subunit CKS1
98D10Haplorrhini (suborder)cyclin-dependent kinase regulatory subunit CKS1
BUZ7HSimiiformes (infraorder)cyclin-dependent kinase regulatory subunit CKS1
9EZWZCatarrhini (parvorder)cyclin-dependent kinase regulatory subunit CKS1
H3BUIBilateria (clade)cyclin-dependent kinase regulatory subunit CKS1
9G8J7Vertebrata (clade)cyclin-dependent kinase regulatory subunit CKS1
7NJAPOpisthokonta (clade)cyclin-dependent kinase regulatory subunit CKS1,glycine N-acyltransferase / glycine N-benzoyltransferase [EC:2.3.1.13 2.3.1.71]
FX2I5Hominoidea (superfamily)cyclin-dependent kinase regulatory subunit CKS1
5N0U4Hominidae (family)cyclin-dependent kinase regulatory subunit CKS1
5Y4B2Homininae (subfamily)cyclin-dependent kinase regulatory subunit CKS1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: