Domains within Homo sapiens protein VWC2_HUMAN (Q2TAL6)

Brorin

Alternative representations: 1 /

Protein length325 aa
Source databaseUniProt
Identifiers VWC2_HUMAN, Q2TAL6, ENSP00000341819.3, ENSP00000341819, Q6UXE2, H9FAY9_MACMU, H9FAY9, U6DXI8_NEOVI, U6DXI8
Source gene ENSG00000188730

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

VWC2_HUMAN is shown as VWC2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for VWC2

Protein VWC2_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03008Ribosome biogenesis in eukaryotes

KEGG orthologous groups

KONameDescription
K24521VWC2brorin

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000341819 in eggNOG.

OGTaxonomic classDescription
73ZH1All organisms (root)brorin,U3 small nucleolar RNA-associated protein 24
5J253Eukaryota (superkingdom)brorin,U3 small nucleolar RNA-associated protein 24
HUDEQMetazoa (kingdom)brorin
93KVFChordata (phylum)brorin
5QBYISarcopterygii (superclass)brorin
8YVUZMammalia (class)brorin
4R696Euarchontoglires (superorder)brorin
4ZNNVPrimates (order)brorin
987F9Haplorrhini (suborder)brorin
BV5G3Simiiformes (infraorder)brorin
9F0N8Catarrhini (parvorder)brorin
H64YIBilateria (clade)brorin
9GC9JVertebrata (clade)brorin
7HTTYOpisthokonta (clade)brorin
FX9GAHominoidea (superfamily)brorin
5N34WHominidae (family)brorin
5XVGDHomininae (subfamily)brorin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: