Domains within Drosophila melanogaster protein Q9VK54_DROME (Q9VK54)

Kekkon-1, isoform B

Alternative representations: 1 /

Protein length880 aa
Source databaseUniProt
Identifiers Q9VK54_DROME, Q9VK54, FBPP0304518, FBPP0312315, B4YXB7_DROME, B4YXB7, Q2XY32_DROME, Q2XY32
Source gene FBgn0015399

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

Q9VK54_DROME is shown as kek1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for kek1

Protein Q9VK54_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04013MAPK signaling pathway - fly
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K22038LRRC8volume-regulated anion channel
K07523LRRC4C, NGL1netrin-G1 ligand
K20230KEK1kekkon-1

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0304518 in eggNOG.

OGTaxonomic classDescription
FE3TXmelanogaster subgroup (species subgroup)kekkon-1
LCOG1552All organisms (root)volume-regulated anion channel,leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein,protein phosphatase 1 regulatory subunit 7
EIZ2REndopterygota (cohort)kekkon-1
FV47Vmelanogaster group (species group)kekkon-1
KOG0619Eukaryota (superkingdom)volume-regulated anion channel,leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein,leucine-rich repeat transmembrane protein FLRT
HT6CPMetazoa (kingdom)netrin-G1 ligand,netrin-G2 ligand,vasorin
HHWGIArthropoda (phylum)kekkon-1
85MY9Hexapoda (subphylum)kekkon-1
AHFVWNeoptera (infraclass)kekkon-1
ANPDVDiptera (order)kekkon-1
H6TYVBilateria (clade)netrin-G1 ligand,netrin-G2 ligand,vasorin
7IK4JOpisthokonta (clade)netrin-G1 ligand,netrin-G2 ligand,leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein
EH3Y8Drosophila (genus)kekkon-1
50E01Sophophora (subgenus)kekkon-1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: