Domains within Rattus norvegicus protein BLNK_RAT (Q4KM52)

B-cell linker protein

Alternative representations: 1 /

Protein length457 aa
Source databaseUniProt
Identifiers BLNK_RAT, Q4KM52, ENSRNOP00000019014.5, ENSRNOP00000019014
Source gene ENSRNOG00000013967

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

BLNK_RAT is shown as Blnk in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Blnk

Protein BLNK_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04380Osteoclast differentiation
map05169Epstein-Barr virus infection
map04662B cell receptor signaling pathway

KEGG orthologous groups

KONameDescription
K05730VAVguanine nucleotide exchange factor VAV
K07371BLNKB-cell linker protein

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 31 PTMs annotated in this protein:

PTMCount
Phosphorylation27
Ubiquitination3
Acetylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Blnk.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000019014 in eggNOG.

OGTaxonomic classDescription
LKOG2996All organisms (root)guanine nucleotide exchange factor VAV,B-cell linker protein,lymphocyte cytosolic protein 2
KOG2996Eukaryota (superkingdom)guanine nucleotide exchange factor VAV,B-cell linker protein,lymphocyte cytosolic protein 2
HSNMBMetazoa (kingdom)B-cell linker protein,lymphocyte cytosolic protein 2
94E2GChordata (phylum)B-cell linker protein
5QY6ISarcopterygii (superclass)B-cell linker protein
8ZDKAMammalia (class)B-cell linker protein
4RN5NEuarchontoglires (superorder)B-cell linker protein
AIDKZRodentia (order)B-cell linker protein
8DFYKMyomorpha (suborder)B-cell linker protein
9FCPDVertebrata (clade)B-cell linker protein
H5E9FBilateria (clade)B-cell linker protein,lymphocyte cytosolic protein 2
7I9NBOpisthokonta (clade)B-cell linker protein,lymphocyte cytosolic protein 2
CQDU1Muridae (family)B-cell linker protein
AE32HMurinae (subfamily)B-cell linker protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: