Domains within Mus musculus protein ACM3_MOUSE (Q9ERZ3)

Muscarinic acetylcholine receptor M3

Alternative representations: 1 /

Protein length589 aa
Source databaseUniProt
Identifiers ACM3_MOUSE, Q9ERZ3, ENSMUSP00000140131.1, ENSMUSP00000140131, ENSMUSP00000055579.9, ENSMUSP00000055579, Q64055, Q542R4_MOUSE, Q542R4
Source gene ENSMUSG00000046159

Predicted functional partners

ACM3_MOUSE is shown as Chrm3 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Chrm3

Protein ACM3_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04971Gastric acid secretion
map04080Neuroactive ligand-receptor interaction
map04020Calcium signaling pathway

KEGG orthologous groups

KONameDescription
K04131CHRM3muscarinic acetylcholine receptor M3
K04133CHRM5muscarinic acetylcholine receptor M5

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 30 PTMs annotated in this protein:

PTMCount
Phosphorylation28
Acetylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Chrm3.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000140131 in eggNOG.

OGTaxonomic classDescription
LKOG4220All organisms (root)muscarinic acetylcholine receptor M3,muscarinic acetylcholine receptor M4,muscarinic acetylcholine receptor M5
KOG4220Eukaryota (superkingdom)muscarinic acetylcholine receptor M3,muscarinic acetylcholine receptor M4,muscarinic acetylcholine receptor M5
HUKJEMetazoa (kingdom)muscarinic acetylcholine receptor M3,muscarinic acetylcholine receptor M5,muscarinic acetylcholine receptor M4
93RM6Chordata (phylum)muscarinic acetylcholine receptor M5,muscarinic acetylcholine receptor M4,muscarinic acetylcholine receptor M3
5QCP3Sarcopterygii (superclass)muscarinic acetylcholine receptor M3,muscarinic acetylcholine receptor M5,muscarinic acetylcholine receptor M1
8YXIGMammalia (class)muscarinic acetylcholine receptor M3,muscarinic acetylcholine receptor M1,muscarinic acetylcholine receptor M5
4RPBCEuarchontoglires (superorder)muscarinic acetylcholine receptor M3,muscarinic acetylcholine receptor M1,muscarinic acetylcholine receptor M5
AI75QRodentia (order)muscarinic acetylcholine receptor M3
8D677Myomorpha (suborder)muscarinic acetylcholine receptor M3
H5JJEBilateria (clade)muscarinic acetylcholine receptor M3,muscarinic acetylcholine receptor M5,muscarinic acetylcholine receptor M4
9FW52Vertebrata (clade)muscarinic acetylcholine receptor M3,muscarinic acetylcholine receptor M5,muscarinic acetylcholine receptor M1
7GTSZOpisthokonta (clade)muscarinic acetylcholine receptor M3,muscarinic acetylcholine receptor M5,muscarinic acetylcholine receptor M4
CQAQTMuridae (family)muscarinic acetylcholine receptor M3
AE55PMurinae (subfamily)muscarinic acetylcholine receptor M3
5PUJUMus (genus)muscarinic acetylcholine receptor M3
HEAAFMus (subgenus)muscarinic acetylcholine receptor M3

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: