Domains within Methanocaldococcus jannaschii DSM 2661 protein RTCB_METJA (Q58095)

tRNA-splicing ligase RtcB

Alternative representations: 1 /

Protein length968 aa
Source databaseUniProt
Identifiers RTCB_METJA, Q58095

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

RTCB_METJA is shown as rtcB in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for rtcB

Protein RTCB_METJA is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03030DNA replication
map01501beta-Lactam resistance

KEGG orthologous groups

KONameDescription
K14415RTCB, rtcBtRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 243232.MJ_0682 in eggNOG.

OGTaxonomic classDescription
72MCVAll organisms (root)tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8],ATP-dependent Lon protease [EC:3.4.21.53],replicative DNA helicase Mcm [EC:5.6.2.3]
LCOG1690All organisms (root)tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8],release factor H-coupled RctB family protein,BPI fold-containing family C
arCOG03158Archaea (superkingdom)tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8],ATP-dependent Lon protease [EC:3.4.21.53],replicative DNA helicase Mcm [EC:5.6.2.3]
arCOG04246Archaea (superkingdom)tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
EM1YPEuryarchaeota (phylum)tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
6SZSRMethanococcales (order)tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
F4JC7Methanocaldococcaceae (family)tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
GWMQ8Methanocaldococcus (genus)tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: