Domains within Drosophila melanogaster protein Q4AB54_DROME (Q4AB54)

Histone H1

Alternative representations: 1 /

Protein length256 aa
Source databaseUniProt
Identifiers Q4AB54_DROME, Q4AB54, FBPP0091107, FBPP0091104, FBPP0091101, Q5BI49_DROME, Q5BI49
Source gene FBgn0053855

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

Q4AB54_DROME is shown as His1:CG33855 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for His1:CG33855

Protein Q4AB54_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04217Necroptosis
map05034Alcoholism

KEGG orthologous groups

KONameDescription
K11251H2Ahistone H2A

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 27 PTMs annotated in this protein:

PTMCount
Phosphorylation21
Acetylation6

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein FBgn0053855.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0091104 in eggNOG.

OGTaxonomic classDescription
7553CAll organisms (root)histone H2A,pleckstrin homology domain-containing family A member 1/2,histone H1/5
EIYM8Endopterygota (cohort)histone H1/5
FV36Imelanogaster group (species group)histone H1/5
FDTTCmelanogaster subgroup (species subgroup)histone H1/5
KOG1756Eukaryota (superkingdom)histone H2A,pleckstrin homology domain-containing family A member 1/2,histone H1/5
HUBAGMetazoa (kingdom)histone H2A,histone H1/5,mature T-cell proliferation-1 type B1
HIX42Arthropoda (phylum)histone H2A,histone H1/5,cytochrome P450 family 4 [EC:1.14.-.-]
86B3QHexapoda (subphylum)histone H2A,histone H1/5,cytochrome P450 family 4 [EC:1.14.-.-]
AHTEBNeoptera (infraclass)histone H1/5
ANXF8Diptera (order)histone H1/5
H5NMXBilateria (clade)histone H2A,histone H1/5,mature T-cell proliferation-1 type B1
7GT9HOpisthokonta (clade)histone H2A,histone H1/5,mature T-cell proliferation-1 type B1
EH19IDrosophila (genus)histone H1/5
50IAGSophophora (subgenus)histone H1/5

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: