Domains within Drosophila melanogaster protein RYK2_DROME (Q9V422)

Tyrosine-protein kinase Dnt

Alternative representations: 1 /

Protein length584 aa
Source databaseUniProt
Identifiers RYK2_DROME, Q9V422, FBPP0307787, FBPP0080765, B9EQS2, O62533, Q5BII5, Q95TI0, M9PG69_DROME, M9PG69
Source gene FBgn0024245

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

RYK2_DROME is shown as dnt in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for dnt

Protein RYK2_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04360Axon guidance

KEGG orthologous groups

KONameDescription
K05128RYKRYK receptor-like tyrosine kinase [EC:2.7.10.1]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0307787 in eggNOG.

OGTaxonomic classDescription
FV540melanogaster group (species group)RYK receptor-like tyrosine kinase [EC:2.7.10.1]
FE2TYmelanogaster subgroup (species subgroup)RYK receptor-like tyrosine kinase [EC:2.7.10.1]
EJ7ZJEndopterygota (cohort)RYK receptor-like tyrosine kinase [EC:2.7.10.1]
LKOG1024All organisms (root)RYK receptor-like tyrosine kinase [EC:2.7.10.1],receptor protein-tyrosine kinase [EC:2.7.10.1]
KOG1024Eukaryota (superkingdom)RYK receptor-like tyrosine kinase [EC:2.7.10.1],receptor protein-tyrosine kinase [EC:2.7.10.1]
HTBNFMetazoa (kingdom)RYK receptor-like tyrosine kinase [EC:2.7.10.1],receptor protein-tyrosine kinase [EC:2.7.10.1]
HHR8RArthropoda (phylum)RYK receptor-like tyrosine kinase [EC:2.7.10.1],receptor protein-tyrosine kinase [EC:2.7.10.1]
85PZSHexapoda (subphylum)RYK receptor-like tyrosine kinase [EC:2.7.10.1],receptor protein-tyrosine kinase [EC:2.7.10.1]
AH811Neoptera (infraclass)RYK receptor-like tyrosine kinase [EC:2.7.10.1],receptor protein-tyrosine kinase [EC:2.7.10.1]
ANXVVDiptera (order)RYK receptor-like tyrosine kinase [EC:2.7.10.1]
H4F6NBilateria (clade)RYK receptor-like tyrosine kinase [EC:2.7.10.1],receptor protein-tyrosine kinase [EC:2.7.10.1]
7N2K0Opisthokonta (clade)RYK receptor-like tyrosine kinase [EC:2.7.10.1],receptor protein-tyrosine kinase [EC:2.7.10.1]
EH2RMDrosophila (genus)RYK receptor-like tyrosine kinase [EC:2.7.10.1]
50C6TSophophora (subgenus)RYK receptor-like tyrosine kinase [EC:2.7.10.1]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: