Domains within Mus musculus protein PEX1_MOUSE (Q5BL07)

Peroxisome biogenesis factor 1

Alternative representations: 1 /

Protein length1284 aa
Source databaseUniProt
Identifiers PEX1_MOUSE, Q5BL07, ENSMUSP00000113304.1, ENSMUSP00000113304, Q3UEC7, Q9CU85, D3Z5A7_MOUSE, D3Z5A7
Source gene ENSMUSG00000005907
Alternative splicing Q5BL07-2, PEX1_MOUSE, ENSMUSP00000116474.1, A0A0G2JE39_MOUSE, F6RUH9_MOUSE, F7CF88_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

PEX1_MOUSE is shown as Pex1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Pex1

Protein PEX1_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04146Peroxisome
map05022Pathways of neurodegeneration - multiple diseases

KEGG orthologous groups

KONameDescription
K13338PEX1peroxin-1
K13525VCP, CDC48transitional endoplasmic reticulum ATPase

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 10 PTMs annotated in this protein:

PTMCount
Phosphorylation9
Ubiquitination1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Pex1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000113304 in eggNOG.

OGTaxonomic classDescription
LCOG0464All organisms (root)transitional endoplasmic reticulum ATPase,vesicle-fusing ATPase [EC:3.6.4.6],ATPase family AAA domain-containing protein 1 [EC:3.6.1.-]
KOG0735Eukaryota (superkingdom)peroxin-1
HVK7UMetazoa (kingdom)peroxin-1
93QX4Chordata (phylum)peroxin-1
5QTY8Sarcopterygii (superclass)peroxin-1
8Z95UMammalia (class)peroxin-1
4R1VKEuarchontoglires (superorder)peroxin-1
AI7JHRodentia (order)peroxin-1
8DC1CMyomorpha (suborder)peroxin-1
9GHZ9Vertebrata (clade)peroxin-1
H3KAABilateria (clade)peroxin-1
7J0USOpisthokonta (clade)peroxin-1
CQ1FDMuridae (family)peroxin-1
AEAXWMurinae (subfamily)peroxin-1
5PFQPMus (genus)peroxin-1
HE922Mus (subgenus)peroxin-1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: