Domains within Drosophila melanogaster protein ATM_DROME (Q5EAK6)

Serine/threonine-protein kinase ATM

Alternative representations: 1 /

Protein length2767 aa
Source databaseUniProt
Identifiers ATM_DROME, Q5EAK6, FBPP0110174, Q0KI71, Q6TKQ1, Q8MZG4, Q9VFB1, B6UYF8_DROME, B6UYF8
Source gene FBgn0045035

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

ATM_DROME is shown as tefu in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for tefu

Protein ATM_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05206MicroRNAs in cancer

KEGG orthologous groups

KONameDescription
K04728ATM, TEL1serine-protein kinase ATM [EC:2.7.11.1]

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 3 PTMs annotated in this protein:

PTMCount
Phosphorylation2
Acetylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein CG6535.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0110174 in eggNOG.

OGTaxonomic classDescription
FDXDUmelanogaster subgroup (species subgroup)serine-protein kinase ATM [EC:2.7.11.1]
FUWQFmelanogaster group (species group)serine-protein kinase ATM [EC:2.7.11.1]
EJBMREndopterygota (cohort)serine-protein kinase ATM [EC:2.7.11.1]
LKOG0892All organisms (root)serine-protein kinase ATM [EC:2.7.11.1]
KOG0892Eukaryota (superkingdom)serine-protein kinase ATM [EC:2.7.11.1]
HTAXTMetazoa (kingdom)serine-protein kinase ATM [EC:2.7.11.1]
HHXX3Arthropoda (phylum)serine-protein kinase ATM [EC:2.7.11.1]
86E9MHexapoda (subphylum)serine-protein kinase ATM [EC:2.7.11.1]
AGU76Neoptera (infraclass)serine-protein kinase ATM [EC:2.7.11.1]
ANG51Diptera (order)serine-protein kinase ATM [EC:2.7.11.1]
7HTV0Opisthokonta (clade)serine-protein kinase ATM [EC:2.7.11.1]
H4I9HBilateria (clade)serine-protein kinase ATM [EC:2.7.11.1]
EGZY4Drosophila (genus)serine-protein kinase ATM [EC:2.7.11.1]
50FTQSophophora (subgenus)serine-protein kinase ATM [EC:2.7.11.1]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: