Domains within Gallus gallus protein RAB8A_CHICK (Q5F470)

Ras-related protein Rab-8A

Alternative representations: 1 /

Protein length207 aa
Source databaseUniProt
Identifiers RAB8A_CHICK, Q5F470, ENSGALP00000041790.1, ENSGALP00000041790, ENSGALP00000064197.1, ENSGALP00000064197
Source gene ENSGALG00000028851

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

RAB8A_CHICK is shown as RAB8A in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for RAB8A

Protein RAB8A_CHICK is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04144Endocytosis
map04530Tight junction
map04972Pancreatic secretion

KEGG orthologous groups

KONameDescription
K07902RAB8BRas-related protein Rab-8B
K07903RAB10Ras-related protein Rab-10
K07901RAB8A, MELRas-related protein Rab-8A

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 16 PTMs annotated in this protein:

PTMCount
Phosphorylation11
Acetylation4
Ubiquitination1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein RAB8A.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9031.ENSGALP00000041790 in eggNOG.

OGTaxonomic classDescription
LKOG0078All organisms (root)Ras-related protein Rab-8A,Ras and EF-hand domain-containing protein,Ras-related protein Rab-40
KOG0078Eukaryota (superkingdom)Ras-related protein Rab-8A,Ras and EF-hand domain-containing protein,Ras-related protein Rab-40
HVKQVMetazoa (kingdom)Ras-related protein Rab-10,Ras-related protein Rab-8A,Ras-related protein Rab-8B
94RITChordata (phylum)Ras-related protein Rab-10,Ras-related protein Rab-8B,Ras-related protein Rab-8A
5QV3SSarcopterygii (superclass)Ras-related protein Rab-8B,Ras-related protein Rab-8A,Ras-related protein Rab-10
6BD5QAves (class)Ras-related protein Rab-8B,Ras-related protein Rab-8A,Ras-related protein Rab-10
8RI28Neognathae (infraclass)Ras-related protein Rab-8A,Ras-related protein Rab-15
BIWWYGalloanserae (superorder)Ras-related protein Rab-8A
AJ3V4Galliformes (order)Ras-related protein Rab-8A
H6SSVBilateria (clade)Ras-related protein Rab-10,Ras-related protein Rab-8A,Ras-related protein Rab-8B
9G36XVertebrata (clade)Ras-related protein Rab-10,Ras-related protein Rab-8B,Ras-related protein Rab-8A
7IMRQOpisthokonta (clade)Ras-related protein Rab-8A,Ras-related protein Rab-10,Ras-related protein Rab-8B
86PKDPhasianidae (family)Ras-related protein Rab-8A
91ZBNPhasianinae (subfamily)Ras-related protein Rab-8A

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: