Domains within Homo sapiens protein BEND3_HUMAN (Q5T5X7)

BEN domain-containing protein 3

Alternative representations: 1 /

Protein length828 aa
Source databaseUniProt
Identifiers BEND3_HUMAN, Q5T5X7, ENSP00000358038.1, ENSP00000358038, ENSP00000411268.2, ENSP00000411268, A2RRH2, Q9HCL9
Source gene ENSG00000178409

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

BEND3_HUMAN is shown as BEND3 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for BEND3

Protein BEND3_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04060Cytokine-cytokine receptor interaction

KEGG orthologous groups

KONameDescription
K21283BMP2bone morphogenetic protein 2

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 28 PTMs annotated in this protein:

PTMCount
Phosphorylation27
SUMOylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein BEND3.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000411268 in eggNOG.

OGTaxonomic classDescription
LKOG3900All organisms (root)bone morphogenetic protein 2,bone morphogenetic protein 7,nodal
KOG3900Eukaryota (superkingdom)bone morphogenetic protein 2,bone morphogenetic protein 7,nodal
HVJH2Metazoa (kingdom)arginine/serine-rich coiled-coil protein 2
93I8QChordata (phylum)BEN,NAD_binding_10,TGFb_propeptide
5QVZWSarcopterygii (superclass)BEN,NAD_binding_10
8Z3QWMammalia (class)BEN,NAD_binding_10
4RMA9Euarchontoglires (superorder)BEN,NAD_binding_10
502FEPrimates (order)BEN
98IU1Haplorrhini (suborder)BEN
BUZYFSimiiformes (infraorder)BEN
9EVV7Catarrhini (parvorder)BEN
H3ZHGBilateria (clade)BEN,NAD_binding_10,TGFb_propeptide
9FE6YVertebrata (clade)BEN,NAD_binding_10,TGFb_propeptide
7IGE8Opisthokonta (clade)arginine/serine-rich coiled-coil protein 2
FX7KKHominoidea (superfamily)BEN
5N6S3Hominidae (family)BEN
5XY5VHomininae (subfamily)BEN

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: