Domains within Homo sapiens protein ANR22_HUMAN (Q5VYY1)

Ankyrin repeat domain-containing protein 22

Alternative representations: 1 /

Protein length191 aa
Source databaseUniProt
Identifiers ANR22_HUMAN, Q5VYY1, ENSP00000360998.4, ENSP00000360998, B2R9Y7, Q8WU06, K7BBG6_PANTR, K7BBG6, H2Q284, G1RNL5_NOMLE, G1RNL5
Source gene ENSG00000152766

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ANR22_HUMAN is shown as ANKRD22 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ANKRD22

Protein ANR22_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05166Human T-cell leukemia virus 1 infection

KEGG orthologous groups

KONameDescription
K10999CESAcellulose synthase A [EC:2.4.1.12]
K06867K06867uncharacterized protein

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000360998 in eggNOG.

OGTaxonomic classDescription
LCOG0666All organisms (root)uncharacterized protein,Mce-associated membrane protein,cellulose synthase A [EC:2.4.1.12]
KOG0504Eukaryota (superkingdom)cellulose synthase A [EC:2.4.1.12],beta-mannan synthase [EC:2.4.1.32],uncharacterized protein
HSRR1Metazoa (kingdom)Ank_2,Ank_4,Ank
9492YChordata (phylum)Ank_2,Ank_4,Ank
5QBHTSarcopterygii (superclass)Ank_2,Ank_4,Ank
8ZNT3Mammalia (class)Ank,Ank_2,Ank_4
4RK09Euarchontoglires (superorder)Ank,Ank_2,Ank_4
4ZXN3Primates (order)Ank_2,Ank_4,Ank
98N9RHaplorrhini (suborder)Ank_4,Ank
BV0W1Simiiformes (infraorder)Ank,Ank_4
9EYFBCatarrhini (parvorder)Ank
7P1UEOpisthokonta (clade)Ank_2,Ank_4,Ank
9GD0JVertebrata (clade)Ank_2,Ank_4,Ank
H4SXRBilateria (clade)Ank_2,Ank_4,Ank
FXAC6Hominoidea (superfamily)Ank
5N3XZHominidae (family)Ank
5XS8HHomininae (subfamily)Ank

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: