Domains within Rattus norvegicus protein KAT8_RAT (Q5XI06)

Histone acetyltransferase KAT8

Alternative representations: 1 /

Protein length458 aa
Source databaseUniProt
Identifiers KAT8_RAT, Q5XI06, ENSRNOP00000026527.3, ENSRNOP00000026527
Source gene ENSRNOG00000019585

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

KAT8_RAT is shown as Kat8 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Kat8

Protein KAT8_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04550Signaling pathways regulating pluripotency of stem cells
map05166Human T-cell leukemia virus 1 infection

KEGG orthologous groups

KONameDescription
K11308MYST1, MOF, KAT8histone acetyltransferase MYST1 [EC:2.3.1.48]
K11307MYST2, HBO1, KAT7histone acetyltransferase MYST2 [EC:2.3.1.48]
K11304TIP60, KAT5, ESA1histone acetyltransferase HTATIP [EC:2.3.1.48]

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 21 PTMs annotated in this protein:

PTMCount
Phosphorylation15
Acetylation5
Methylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Myst1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000026527 in eggNOG.

OGTaxonomic classDescription
LKOG2747All organisms (root)histone acetyltransferase MYST1 [EC:2.3.1.48],histone acetyltransferase HTATIP [EC:2.3.1.48],histone acetyltransferase MYST2 [EC:2.3.1.48]
KOG2747Eukaryota (superkingdom)histone acetyltransferase MYST1 [EC:2.3.1.48],histone acetyltransferase HTATIP [EC:2.3.1.48],histone acetyltransferase MYST2 [EC:2.3.1.48]
HW6VYMetazoa (kingdom)histone acetyltransferase MYST2 [EC:2.3.1.48],histone acetyltransferase MYST1 [EC:2.3.1.48],histone acetyltransferase HTATIP [EC:2.3.1.48]
941PKChordata (phylum)histone acetyltransferase MYST2 [EC:2.3.1.48],histone acetyltransferase MYST3 [EC:2.3.1.48],histone acetyltransferase MYST1 [EC:2.3.1.48]
5R0GHSarcopterygii (superclass)histone acetyltransferase MYST1 [EC:2.3.1.48],histone acetyltransferase MYST2 [EC:2.3.1.48],histone acetyltransferase HTATIP [EC:2.3.1.48]
8ZB29Mammalia (class)histone acetyltransferase MYST1 [EC:2.3.1.48]
4R7KPEuarchontoglires (superorder)histone acetyltransferase MYST1 [EC:2.3.1.48]
AI9IARodentia (order)histone acetyltransferase MYST1 [EC:2.3.1.48]
8DH60Myomorpha (suborder)histone acetyltransferase MYST1 [EC:2.3.1.48]
H678ZBilateria (clade)histone acetyltransferase MYST2 [EC:2.3.1.48],histone acetyltransferase MYST1 [EC:2.3.1.48],histone acetyltransferase HTATIP [EC:2.3.1.48]
9GINXVertebrata (clade)histone acetyltransferase MYST2 [EC:2.3.1.48],histone acetyltransferase MYST3 [EC:2.3.1.48],histone acetyltransferase MYST1 [EC:2.3.1.48]
7MKESOpisthokonta (clade)histone acetyltransferase HTATIP [EC:2.3.1.48],histone acetyltransferase MYST2 [EC:2.3.1.48],histone acetyltransferase MYST1 [EC:2.3.1.48]
CQ932Muridae (family)histone acetyltransferase MYST1 [EC:2.3.1.48]
AEB9DMurinae (subfamily)histone acetyltransferase MYST1 [EC:2.3.1.48]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: