Domains within Mus musculus protein PLA2R_MOUSE (Q62028)

Secretory phospholipase A2 receptor

Alternative representations: 1 /

Protein length1487 aa
Source databaseUniProt
Identifiers PLA2R_MOUSE, Q62028, ENSMUSP00000108144.3, ENSMUSP00000108144, A2AS64, B9EJ68, Q80ZL5
Source gene ENSMUSG00000054580

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Euteleostomi

Predicted functional partners

PLA2R_MOUSE is shown as Pla2r1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Pla2r1

Protein PLA2R_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04145Phagosome
map05152Tuberculosis

KEGG orthologous groups

KONameDescription
K06560MRC, CD206, CD280mannose receptor, C type

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000108144 in eggNOG.

OGTaxonomic classDescription
LKOG4297All organisms (root)mannose receptor, C type,CUB and sushi domain-containing protein,E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
KOG4297Eukaryota (superkingdom)mannose receptor, C type,CUB and sushi domain-containing protein,E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
HVHZ4Metazoa (kingdom)mannose receptor, C type,regenerating islet-derived protein 4,8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
94W6GChordata (phylum)mannose receptor, C type,C-type lectin domain family 4 member M,collectin sub-family member 12
5R64XSarcopterygii (superclass)mannose receptor, C type
8Z36SMammalia (class)mannose receptor, C type
4RSCMEuarchontoglires (superorder)mannose receptor, C type
AI51PRodentia (order)mannose receptor, C type
8DCWFMyomorpha (suborder)mannose receptor, C type
H4DS6Bilateria (clade)mannose receptor, C type,regenerating islet-derived protein 4,C-type lectin domain family 4 member E
7MCFYOpisthokonta (clade)mannose receptor, C type,regenerating islet-derived protein 4,8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
9FZ5EVertebrata (clade)mannose receptor, C type,C-type lectin domain family 4 member M,collectin sub-family member 12
CQCPKMuridae (family)mannose receptor, C type
AE4QHMurinae (subfamily)mannose receptor, C type
5PV2RMus (genus)mannose receptor, C type
HE37TMus (subgenus)mannose receptor, C type

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: