Domains within Bos taurus protein FADD_BOVIN (Q645M6)

FAS-associated death domain protein

Alternative representations: 1 /

Protein length209 aa
Source databaseUniProt
Identifiers FADD_BOVIN, Q645M6, ENSBTAP00000024322.4, ENSBTAP00000024322
Source gene ENSBTAG00000018274

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Euteleostomi

Predicted functional partners

FADD_BOVIN is shown as FADD in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for FADD

Protein FADD_BOVIN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04621NOD-like receptor signaling pathway
map04360Axon guidance
map04936Alcoholic liver disease

KEGG orthologous groups

KONameDescription
K23698SLAsrc-like-adapter
K02373FADDFAS-associated death domain protein
K08852ERN1serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9913.ENSBTAP00000024322 in eggNOG.

OGTaxonomic classDescription
LCOG0478All organisms (root)serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-],RAC serine/threonine-protein kinase [EC:2.7.11.1],pto-interacting protein 1 [EC:2.7.11.1]
KOG0192Eukaryota (superkingdom)src-like-adapter,sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25],ubiquinol oxidase [EC:1.10.3.11]
HUYAPMetazoa (kingdom)FAS-associated death domain protein
93KBGChordata (phylum)FAS-associated death domain protein
5QP42Sarcopterygii (superclass)FAS-associated death domain protein
8ZMMIMammalia (class)FAS-associated death domain protein
BQTADLaurasiatheria (superorder)FAS-associated death domain protein
AXD6NArtiodactyla (order)FAS-associated death domain protein
B6E3TPecora (infraorder)FAS-associated death domain protein
7MZG9Opisthokonta (clade)FAS-associated death domain protein
9GAXTVertebrata (clade)FAS-associated death domain protein
H60CYBilateria (clade)FAS-associated death domain protein
7PRBBBovidae (family)FAS-associated death domain protein
DATJFBovinae (subfamily)FAS-associated death domain protein
AZN6XBos (genus)FAS-associated death domain protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: