Domains within Rattus norvegicus protein Q66H91_RAT (Q66H91)

G protein-coupled receptor kinase interacting ArfGAP 2

Alternative representations: 1 /

Protein length759 aa
Source databaseUniProt
Identifiers Q66H91_RAT, Q66H91, ENSRNOP00000048331.2, ENSRNOP00000048331
Source gene ENSRNOG00000001190

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

Q66H91_RAT is shown as Git2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Git2

Protein Q66H91_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04144Endocytosis
map05135Yersinia infection

KEGG orthologous groups

KONameDescription
K12487GIT2G protein-coupled receptor kinase interactor 2

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 38 PTMs annotated in this protein:

PTMCount
Phosphorylation37
Caspase cleavage aspartic acid1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Git2.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000048331 in eggNOG.

OGTaxonomic classDescription
LKOG0818All organisms (root)G protein-coupled receptor kinase interactor 2,G protein-coupled receptor kinase interactor 1,abhydrolase domain-containing protein 15
KOG0818Eukaryota (superkingdom)G protein-coupled receptor kinase interactor 2,G protein-coupled receptor kinase interactor 1,abhydrolase domain-containing protein 15
HURTHMetazoa (kingdom)G protein-coupled receptor kinase interactor 2,G protein-coupled receptor kinase interactor 1
94N22Chordata (phylum)G protein-coupled receptor kinase interactor 2,G protein-coupled receptor kinase interactor 1
5R7AUSarcopterygii (superclass)G protein-coupled receptor kinase interactor 2,G protein-coupled receptor kinase interactor 1
8ZCZJMammalia (class)G protein-coupled receptor kinase interactor 2
4R51CEuarchontoglires (superorder)G protein-coupled receptor kinase interactor 2
AI414Rodentia (order)G protein-coupled receptor kinase interactor 2
8DNT1Myomorpha (suborder)G protein-coupled receptor kinase interactor 2
9GNPBVertebrata (clade)G protein-coupled receptor kinase interactor 2,G protein-coupled receptor kinase interactor 1
H4XPRBilateria (clade)G protein-coupled receptor kinase interactor 2,G protein-coupled receptor kinase interactor 1
7GR27Opisthokonta (clade)G protein-coupled receptor kinase interactor 2,G protein-coupled receptor kinase interactor 1
CQ8PKMuridae (family)G protein-coupled receptor kinase interactor 2
AE9RAMurinae (subfamily)G protein-coupled receptor kinase interactor 2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: