Domains within Mus musculus protein CDC5L_MOUSE (Q6A068)

Cell division cycle 5-like protein

Alternative representations: 1 /

Protein length802 aa
Source databaseUniProt
Identifiers CDC5L_MOUSE, Q6A068, ENSMUSP00000024727.8, ENSMUSP00000024727, Q8K1J9, Q3UCF2_MOUSE, Q3UCF2
Source gene ENSMUSG00000023932

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

CDC5L_MOUSE is shown as Cdc5l in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Cdc5l

Protein CDC5L_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03040Spliceosome

KEGG orthologous groups

KONameDescription
K12860CDC5L, CDC5, CEF1pre-mRNA-splicing factor CDC5/CEF1

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 48 PTMs annotated in this protein:

PTMCount
Phosphorylation38
Ubiquitination5
Acetylation3
Nitrosylation1
Caspase cleavage aspartic acid1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Cdc5l.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000024727 in eggNOG.

OGTaxonomic classDescription
LKOG0050All organisms (root)pre-mRNA-splicing factor CDC5/CEF1
KOG0050Eukaryota (superkingdom)pre-mRNA-splicing factor CDC5/CEF1
HVZUJMetazoa (kingdom)pre-mRNA-splicing factor CDC5/CEF1
94AUBChordata (phylum)pre-mRNA-splicing factor CDC5/CEF1
5QM7WSarcopterygii (superclass)pre-mRNA-splicing factor CDC5/CEF1
8Z2J5Mammalia (class)pre-mRNA-splicing factor CDC5/CEF1
4RGMBEuarchontoglires (superorder)pre-mRNA-splicing factor CDC5/CEF1
AIFJURodentia (order)pre-mRNA-splicing factor CDC5/CEF1
8DJEHMyomorpha (suborder)pre-mRNA-splicing factor CDC5/CEF1
H3IQIBilateria (clade)pre-mRNA-splicing factor CDC5/CEF1
7H4J4Opisthokonta (clade)pre-mRNA-splicing factor CDC5/CEF1
9FBAPVertebrata (clade)pre-mRNA-splicing factor CDC5/CEF1
CQ41WMuridae (family)pre-mRNA-splicing factor CDC5/CEF1
AEA35Murinae (subfamily)pre-mRNA-splicing factor CDC5/CEF1
5PT90Mus (genus)pre-mRNA-splicing factor CDC5/CEF1
HEDVMMus (subgenus)pre-mRNA-splicing factor CDC5/CEF1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: