Domains within Drosophila melanogaster protein A1Z9D7_DROME (A1Z9D7)

Low-density lipoprotein receptor-related protein

Alternative representations: 1 /

Protein length1678 aa
Source databaseUniProt
Identifiers A1Z9D7_DROME, A1Z9D7, FBPP0086821, Q6AWJ8_DROME, Q6AWJ8
Source gene FBgn0000119

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

A1Z9D7_DROME is shown as arr in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for arr

Protein A1Z9D7_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05010Alzheimer disease
map04928Parathyroid hormone synthesis, secretion and action
map04979Cholesterol metabolism

KEGG orthologous groups

KONameDescription
K03068LRP5_6low density lipoprotein receptor-related protein 5/6
K20050LRP3_10_12low-density lipoprotein receptor-related protein 3/10/12

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 21 PTMs annotated in this protein:

PTMCount
Phosphorylation15
N-linked glycosylation4
Methylation1
Ubiquitination1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein arr.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0086821 in eggNOG.

OGTaxonomic classDescription
EJDICEndopterygota (cohort)low density lipoprotein receptor-related protein 5/6
LKOG1215All organisms (root)low-density lipoprotein receptor-related protein 3/10/12,low density lipoprotein receptor-related protein 5/6,low-density lipoprotein receptor-related protein 4
FUX81melanogaster group (species group)low density lipoprotein receptor-related protein 5/6
FE5JFmelanogaster subgroup (species subgroup)low density lipoprotein receptor-related protein 5/6
KOG1215Eukaryota (superkingdom)low-density lipoprotein receptor-related protein 3/10/12,low density lipoprotein receptor-related protein 5/6,low-density lipoprotein receptor-related protein 4
HVGZ5Metazoa (kingdom)low density lipoprotein receptor-related protein 5/6,low density lipoprotein-related protein 2,low-density lipoprotein receptor-related protein 4
HIAMXArthropoda (phylum)low density lipoprotein receptor-related protein 5/6
867YEHexapoda (subphylum)low density lipoprotein receptor-related protein 5/6
AHMAKNeoptera (infraclass)low density lipoprotein receptor-related protein 5/6
ANGVEDiptera (order)low density lipoprotein receptor-related protein 5/6
7J6BYOpisthokonta (clade)low density lipoprotein receptor-related protein 5/6,low density lipoprotein-related protein 2,low-density lipoprotein receptor-related protein 4
H4RPUBilateria (clade)low density lipoprotein receptor-related protein 5/6,low density lipoprotein-related protein 2,low-density lipoprotein receptor-related protein 4
EH2VUDrosophila (genus)low density lipoprotein receptor-related protein 5/6
50BUCSophophora (subgenus)low density lipoprotein receptor-related protein 5/6

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: