Domains within Kluyveromyces lactis NRRL Y-1140 protein ATG18_KLULA (Q6CS21)

Autophagy-related protein 18

Alternative representations: 1 /

Protein length500 aa
Source databaseUniProt
Identifiers ATG18_KLULA, Q6CS21

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ATG18_KLULA is shown as ATG18 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ATG18

Protein ATG18_KLULA is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05016Huntington disease

KEGG orthologous groups

KONameDescription
K17908WIPI1_2, ATG18autophagy-related protein 18

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 284590.Q6CS21 in eggNOG.

OGTaxonomic classDescription
LKOG2110All organisms (root)autophagy-related protein 18,WD repeat-containing protein 45,MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 6
FS0CCDikarya (subkingdom)autophagy-related protein 18
KOG2110Eukaryota (superkingdom)autophagy-related protein 18,WD repeat-containing protein 45,MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 6
BMYBHFungi (kingdom)autophagy-related protein 18
9SDREAscomycota (phylum)autophagy-related protein 18
91IHDSaccharomycetales (order)autophagy-related protein 18
7NA1EOpisthokonta (clade)autophagy-related protein 18,MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 6
AT7BPSaccharomycetaceae (family)autophagy-related protein 18

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: